Blood Co-Circulating Extracellular microRNAs and Immune Cell Subsets Associate with Type 1 Diabetes Severity.
autoimmune
biomarkers
lymphocytes
microRNAs
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Jan 2020
11 Jan 2020
Historique:
received:
29
11
2019
revised:
06
01
2020
accepted:
09
01
2020
entrez:
17
1
2020
pubmed:
17
1
2020
medline:
4
6
2020
Statut:
epublish
Résumé
Immune cell subsets and microRNAs have been independently proposed as type 1 diabetes (T1D) diagnostic and/or prognostic biomarkers. Here, we aimed to analyze the relationships between peripheral blood circulating immune cell subsets, plasmatic microRNAs, and T1D. Blood samples were obtained from both children with T1D at diagnosis and age-sex matched healthy controls. Then, immunophenotype assessed by flow cytometry was coupled with the quantification of 60 plasmatic microRNAs by quantitative RT-PCR. The associations between immune cell frequency, plasmatic microRNAs, and the parameters of pancreatic loss, glycemic control, and diabetic ketoacidosis were assessed by logistic regression models and correlation analyses. We found that the increase in specific plasmatic microRNAs was associated with T1D disease onset (let-7c-5p, let-7d-5p, let-7f-5p, let-7i-5p, miR-146a-5p, miR-423-3p, and miR-423-5p), serum C-peptide concentration (miR-142-5p and miR-29c-3p), glycated hemoglobin (miR-26a-5p and miR-223-3p) and the presence of ketoacidosis (miR-29c-3p) more strongly than the evaluated immune cell subset frequency. Some of these plasmatic microRNAs were shown to positively correlate with numbers of blood circulating B lymphocytes (miR-142-5p) and CD4
Identifiants
pubmed: 31940853
pii: ijms21020477
doi: 10.3390/ijms21020477
pmc: PMC7013659
pii:
doi:
Substances chimiques
Biomarkers
0
Circulating MicroRNA
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Juvenile Diabetes Research Foundation International
ID : 1-SRA-2018-477-S-B
Organisme : Juvenile Diabetes Research Foundation International
ID : 2-SRA-2018-479-S-B
Organisme : European Foundation for the Study of Diabetes
ID : EFSD/JDRF Lily program 2015
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