Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics.
blood–brain barrier (BBB)
central nervous system (CNS)
drug delivery systems
nanotechnology
polymeric nanoparticles
theranostics
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
13 Jan 2020
13 Jan 2020
Historique:
received:
10
11
2019
revised:
19
12
2019
accepted:
06
01
2020
entrez:
17
1
2020
pubmed:
17
1
2020
medline:
17
1
2020
Statut:
epublish
Résumé
The blood-brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.
Identifiants
pubmed: 31941057
pii: biomedicines8010013
doi: 10.3390/biomedicines8010013
pmc: PMC7168063
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Control Release. 2003 Dec 5;93(2):151-60
pubmed: 14636721
Int J Biomater. 2009;2009:239643
pubmed: 20126577
Cells. 2018 Mar 23;7(4):
pubmed: 29570659
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Sep-Oct;1(5):463-74
pubmed: 20049811
Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):1-18
pubmed: 19782542
J Neurosci Methods. 2001 Oct 30;111(2):151-5
pubmed: 11595281
J Biomater Appl. 2013 Mar;27(7):909-22
pubmed: 22207601
J Clin Neurosci. 2018 Jul;53:1-5
pubmed: 29706419
Eur J Pharm Biopharm. 2011 Jan;77(1):84-8
pubmed: 21074612
J Photochem Photobiol B. 2019 Jan;190:98-102
pubmed: 30504054
Adv Mater. 2018 Nov;30(46):e1801362
pubmed: 30066406
Nanomedicine. 2015 Oct;11(7):1603-11
pubmed: 25989200
Neurobiol Dis. 2010 Jan;37(1):13-25
pubmed: 19664713
Int J Pharm. 2006 Mar 9;310(1-2):213-9
pubmed: 16426779
Int J Pharm. 2018 Nov 15;551(1-2):329-338
pubmed: 30244148
Sci Rep. 2016 Aug 09;6:31036
pubmed: 27503340
Biomacromolecules. 2018 Aug 13;19(8):3361-3370
pubmed: 29940101
Clin Pharmacokinet. 2001;40(12):907-46
pubmed: 11735609
Eur J Pharm Sci. 2000 Oct;11(4):265-83
pubmed: 11033070
Int J Biol Macromol. 2019 Jul 15;133:603-613
pubmed: 31004642
Int J Pharm. 2005 May 13;295(1-2):247-60
pubmed: 15848009
J Control Release. 2011 Mar 10;150(2):220-8
pubmed: 21111014
Eur J Pharm Biopharm. 2010 Oct;76(2):189-99
pubmed: 20637869
Int J Radiat Biol. 2018 Nov;94(11):1027-1037
pubmed: 29985733
J Control Release. 2017 Oct 28;264:102-111
pubmed: 28842313
J Pharmacol Exp Ther. 2006 Jun;317(3):1246-53
pubmed: 16554356
Pharm Res. 1994 Aug;11(8):1186-9
pubmed: 7971722
Pharm Res. 1997 Mar;14(3):325-8
pubmed: 9098875
Int J Nanomedicine. 2012;7:5577-91
pubmed: 23144561
J Mater Sci Mater Med. 2010 Jan;21(1):343-51
pubmed: 19653069
Mol Pharm. 2016 Nov 7;13(11):3976-3987
pubmed: 27700119
Drug Deliv. 2017 Nov;24(1):1112-1123
pubmed: 28782388
Int J Nanomedicine. 2015 Jul 16;10:4535-47
pubmed: 26213467
Placenta. 2017 Jun;54:111-116
pubmed: 27939102
Pharm Res. 2003 Mar;20(3):409-16
pubmed: 12669961
Int J Pharm. 2019 Apr 5;560:92-100
pubmed: 30742988
J Biomed Biotechnol. 2009;2009:571702
pubmed: 19789653
Carbohydr Polym. 2017 Feb 10;157:419-428
pubmed: 27987946
Toxicol Lett. 2011 Sep 25;206(1):60-6
pubmed: 21726608
Autophagy. 2019 Jan;15(1):4-33
pubmed: 30160607
PLoS One. 2012;7(3):e32568
pubmed: 22396775
Am J Transl Res. 2016 Feb 15;8(2):749-64
pubmed: 27158367
Drug Deliv. 2018 Nov;25(1):1634-1641
pubmed: 30176744
Pharm Res. 1999 Dec;16(12):1836-42
pubmed: 10644071
J Microencapsul. 2005 Nov;22(7):773-85
pubmed: 16421087
Int J Pharm. 2012 Oct 15;436(1-2):840-50
pubmed: 22841849
Prog Neurobiol. 2009 Apr;87(4):212-51
pubmed: 19395337
Expert Opin Drug Deliv. 2009 Apr;6(4):371-87
pubmed: 19382881
Biomaterials. 2011 Jul;32(21):4943-50
pubmed: 21470674
J Drug Target. 2007 Dec;15(10):641-63
pubmed: 18041633
Int J Biol Macromol. 2018 Feb;107(Pt A):204-211
pubmed: 28863897
Nat Commun. 2017 May 19;8:15322
pubmed: 28524852
Biomaterials. 2010 Feb;31(5):908-15
pubmed: 19853292
J Microencapsul. 1998 Jan-Feb;15(1):67-74
pubmed: 9463808
Curr Pharm Des. 2009;15(2):153-72
pubmed: 19149610
Molecules. 2018 May 28;23(6):
pubmed: 29843371
Neurobiol Dis. 2010 Jan;37(1):33-7
pubmed: 19664709
Nanomaterials (Basel). 2018 Aug 21;8(9):
pubmed: 30134524
Neurol Clin. 2018 Aug;36(3):449-466
pubmed: 30072065
Int J Biol Macromol. 2020 Feb 15;145:282-300
pubmed: 31870872
J Control Release. 2009 Jul 1;137(1):78-86
pubmed: 19285109
Chem Pharm Bull (Tokyo). 2010 Nov;58(11):1423-30
pubmed: 21048331
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):
pubmed: 28716886
Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1605-1616
pubmed: 28974108
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:488-492
pubmed: 28392484
Acta Pharm. 2008 Mar;58(1):61-74
pubmed: 18337208
Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:32-38
pubmed: 28575990
J Control Release. 2018 Jan 28;270:290-303
pubmed: 29269142
Drug Dev Ind Pharm. 2017 Jan;43(1):12-21
pubmed: 27277750
J Control Release. 2007 Jan 22;117(1):51-8
pubmed: 17150277
Nat Rev Neurol. 2018 Mar;14(3):133-150
pubmed: 29377008
J Pharm Pharmacol. 2018 Jan;70(1):59-69
pubmed: 29034965
Trends Mol Med. 2003 Jul;9(7):307-12
pubmed: 12900218
Int J Biol Macromol. 2017 Apr;97:744-751
pubmed: 28109815
Biomacromolecules. 2001 Fall;2(3):806-11
pubmed: 11710035
J Control Release. 2008 Dec 18;132(3):171-83
pubmed: 18582981
Neurosci Biobehav Rev. 2018 Jul;90:26-33
pubmed: 29608988
J Adv Res. 2019 Jan 18;18:81-93
pubmed: 30828478
Curr Drug Deliv. 2009 Jul;6(3):261-73
pubmed: 19604140
Beilstein J Nanotechnol. 2017 Jul 12;8:1446-1456
pubmed: 28900598
Mol Pharm. 2019 Apr 1;16(4):1433-1443
pubmed: 30803231
Acta Biomater. 2012 Jan;8(1):218-24
pubmed: 21878398
Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:165-174
pubmed: 28415451
Curr Clin Pharmacol. 2018;13(2):110-119
pubmed: 29651960
ACS Nano. 2018 May 22;12(5):4123-4139
pubmed: 29617109
J Microbiol Biotechnol. 2019 Jul 28;29(7):1096-1103
pubmed: 31091866
J Microencapsul. 2006 Aug;23(5):582-92
pubmed: 16980278
Chem Soc Rev. 2019 Jun 4;48(11):2967-3014
pubmed: 31089607
Mater Sci Eng C Mater Biol Appl. 2017 May 1;74:167-176
pubmed: 28254282
Adv Healthc Mater. 2019 Jan;8(2):e1801359
pubmed: 30549448
J Pharm Sci. 2008 Apr;97(4):1530-42
pubmed: 17722098
J Pharm Pharmacol. 1979 May;31(5):331-2
pubmed: 37304
J Drug Target. 2017 Jan;25(1):17-28
pubmed: 27126681
Materials (Basel). 2016 Sep 24;9(10):
pubmed: 28773918
Nanotheranostics. 2018 Jan 1;2(1):70-86
pubmed: 29291164
J Pharmacol Exp Ther. 2002 Dec;303(3):928-36
pubmed: 12438511
Prog Drug Res. 1998;51:95-131
pubmed: 9949860
Neurotherapeutics. 2009 Apr;6(2):359-71
pubmed: 19332331
J Control Release. 2007 Sep 11;122(1):1-9
pubmed: 17651855
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):247-79
pubmed: 11259843
J Drug Target. 2015;23(7-8):736-49
pubmed: 26453169
ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30201-30213
pubmed: 30113810
Eur J Pharm Biopharm. 2008 Sep;70(1):75-84
pubmed: 18472255
Cold Spring Harb Perspect Biol. 2015 Jan 05;7(1):a020412
pubmed: 25561720
Nanomedicine (Lond). 2009 Jan;4(1):105-18
pubmed: 19093899
Brain Res. 2008 Mar 20;1200:159-68
pubmed: 18291351
Bull Exp Biol Med. 2008 Feb;145(2):259-62
pubmed: 19023984
J Nanosci Nanotechnol. 2006 Sep-Oct;6(9-10):3040-7
pubmed: 17048516
Mater Sci Eng C Mater Biol Appl. 2018 Oct 1;91:445-457
pubmed: 30033276
Drug Deliv Transl Res. 2017 Aug;7(4):497-506
pubmed: 28315051
Acta Pharm Sin B. 2018 Jan;8(1):85-96
pubmed: 29872625
Nanomedicine. 2018 Feb;14(2):609-618
pubmed: 29248676
Curr Pharm Des. 2017;23(3):393-410
pubmed: 27799038
Expert Opin Drug Deliv. 2015;12(9):1547-63
pubmed: 25943722
Neuroscience. 2008 Mar 27;152(3):785-97
pubmed: 18304744
Expert Opin Drug Deliv. 2008 Feb;5(2):155-74
pubmed: 18248316
Int J Pharm. 2007 Sep 5;342(1-2):208-14
pubmed: 17560058
ACS Appl Mater Interfaces. 2017 Mar 22;9(11):9516-9527
pubmed: 28247754
Eur J Pharm Biopharm. 2009 Feb;71(2):251-6
pubmed: 18805484
Physiol Rev. 2019 Jan 1;99(1):21-78
pubmed: 30280653
J Drug Target. 2011 Feb;19(2):125-32
pubmed: 20387992
Oncotarget. 2017 Jan 24;8(4):6564-6578
pubmed: 28036254
J Drug Target. 2008 Jun;16(5):415-23
pubmed: 18569286
Pharm Res. 2001 Aug;18(8):1157-66
pubmed: 11587488
Curr Drug Deliv. 2020;17(1):15-22
pubmed: 31721702
Clin Anat. 2018 Sep;31(6):812-823
pubmed: 29637627
Pharmaceutics. 2019 Feb 07;11(2):
pubmed: 30736486
Eur J Pharm Biopharm. 2018 Aug;129:74-79
pubmed: 29802982
Mol Pharm. 2010 Jun 7;7(3):815-25
pubmed: 20230014
Brain Res Bull. 2018 Oct;143:155-170
pubmed: 30449731
Expert Opin Drug Deliv. 2019 Mar;16(3):271-285
pubmed: 30767695
NeuroRx. 2005 Jan;2(1):3-14
pubmed: 15717053
Eur J Med Chem. 2018 Sep 5;157:1153-1163
pubmed: 30189397
Nanomaterials (Basel). 2015 Aug 19;5(3):1351-1365
pubmed: 28347068
Adv Drug Deliv Rev. 2003 Apr 25;55(4):501-18
pubmed: 12706048
Sci Rep. 2017 Sep 11;7(1):11086
pubmed: 28894228
Oncotarget. 2017 Dec 15;9(3):3459-3482
pubmed: 29423059
Materials (Basel). 2014 Apr 17;7(4):3106-3135
pubmed: 28788609
Int J Biol Macromol. 2018 Apr 1;109:27-35
pubmed: 29247729
NeuroRx. 2005 Jan;2(1):108-19
pubmed: 15717062
Brain Res. 1995 Mar 13;674(1):171-4
pubmed: 7773690
Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7132-6
pubmed: 22744941
J Ind Eng Chem. 2019 May 25;73:8-18
pubmed: 31588177
J Control Release. 2007 Mar 12;118(1):38-53
pubmed: 17240471
Trends Biotechnol. 2009 Nov;27(11):628-35
pubmed: 19766335
Biopharm Drug Dispos. 2008 Nov;29(8):431-9
pubmed: 18837064
Angew Chem Int Ed Engl. 2008;47(50):9726-9
pubmed: 18979480
Int J Pharm. 2018 Jul 10;545(1-2):84-92
pubmed: 29715532
J Pharm Sci. 2019 May;108(5):1736-1745
pubmed: 30552956
Pharm Res. 1999 Oct;16(10):1564-9
pubmed: 10554098
Nanomedicine (Lond). 2008 Jun;3(3):367-93
pubmed: 18510431
Nature. 2018 Sep;561(7724):S40-S41
pubmed: 30258156
Int J Pharm. 2001 Aug 14;224(1-2):159-68
pubmed: 11472825
Semin Cell Dev Biol. 2015 Feb;38:2-6
pubmed: 25681530
Nanomedicine (Lond). 2018 Jul;13(13):1513-1516
pubmed: 29998779
J Neurosci Methods. 2019 Jan 1;311:133-146
pubmed: 30336221
Nanoscale. 2018 Sep 20;10(36):16962-16983
pubmed: 30182106
Biomed Pharmacother. 2018 Aug;104:465-473
pubmed: 29793179
Oncotarget. 2017 Sep 15;8(46):81001-81013
pubmed: 29113362
Int J Nanomedicine. 2012;7:1031-41
pubmed: 22403486
Nanomedicine (Lond). 2015;10(11):1735-50
pubmed: 26080696
Bioconjug Chem. 2005 Nov-Dec;16(6):1503-11
pubmed: 16287248
J Drug Target. 2019 Jun - Jul;27(5-6):470-501
pubmed: 30720372
Biomolecules. 2019 Sep 25;9(10):
pubmed: 31557936
Int J Mol Sci. 2019 Jun 25;20(12):
pubmed: 31242683
ACS Nano. 2009 Jan 27;3(1):16-20
pubmed: 19206243
Mol Biotechnol. 2005 May;30(1):57-70
pubmed: 15805577
Drug Deliv. 2015 May;22(3):243-57
pubmed: 24471801
Curr Top Med Chem. 2009;9(2):182-96
pubmed: 19200004
J Transl Med. 2009 Sep 01;7:77
pubmed: 19723323
Biomaterials. 2011 Nov;32(31):8010-20
pubmed: 21788069
Acta Biomater. 2015 Sep;24:140-51
pubmed: 26116986
Drug Discov Today. 2008 Dec;13(23-24):1099-106
pubmed: 18848640
J Funct Biomater. 2019 Jan 08;10(1):
pubmed: 30626094
J Drug Target. 2006 Feb;14(2):97-105
pubmed: 16608736
J Cell Physiol. 2019 Feb;234(2):1547-1559
pubmed: 30145790
J Neuroimmunol. 2009 Aug 18;213(1-2):20-5
pubmed: 19564052
J Nanobiotechnology. 2018 Mar 27;16(1):32
pubmed: 29587747
J Pharm Sci. 2005 Jun;94(6):1343-53
pubmed: 15858853
Int J Pharm. 2009 Sep 8;379(1):146-57
pubmed: 19555750
Neurol Clin. 2018 Nov;36(4):865-897
pubmed: 30366560
J Drug Target. 2006 Jan;14(1):45-53
pubmed: 16603451
Int J Pharm. 2017 Jun 15;525(1):237-248
pubmed: 28432017
Drug Discov Today. 2002 Jan 1;7(1):5-7
pubmed: 11790589
Sci Rep. 2019 Jun 4;9(1):8278
pubmed: 31164665
Pharmaceutics. 2018 Dec 11;10(4):
pubmed: 30544966
Int J Biol Macromol. 2019 Mar 15;125:785-790
pubmed: 30543880
Drug Res (Stuttg). 2018 Oct;68(10):584-595
pubmed: 29669380
Drug Des Devel Ther. 2019 Sep 26;13:3405-3418
pubmed: 31579238
Brain Res. 2009 Mar 19;1261:91-9
pubmed: 19401168
CNS Neurol Disord Drug Targets. 2009 Jun;8(3):205-21
pubmed: 19601818
J Drug Target. 2002 Jun;10(4):317-25
pubmed: 12164380
Biomaterials. 2018 Apr;161:95-105
pubmed: 29421566
Cells. 2019 Sep 27;8(10):
pubmed: 31569687
J Nanobiotechnology. 2018 Feb 13;16(1):13
pubmed: 29433522
Carbohydr Polym. 2018 Jan 15;180:365-375
pubmed: 29103516
Int J Pharm. 2011 Oct 31;419(1-2):296-307
pubmed: 21821107
Int J Pharm. 2019 Mar 25;559:360-372
pubmed: 30721725
Crit Rev Ther Drug Carrier Syst. 2002;19(1):73-98
pubmed: 12046892
Eur J Pharm Biopharm. 2008 Nov;70(3):735-40
pubmed: 18684400
Pharm Res. 1998 Sep;15(9):1326-31
pubmed: 9755881
Lancet Psychiatry. 2018 Jan;5(1):79-92
pubmed: 28781208
Biomaterials. 2010 Oct;31(30):7748-57
pubmed: 20673685
Adv Drug Deliv Rev. 1997 Oct 13;28(1):5-24
pubmed: 10837562
Eur J Pharm Biopharm. 2010 Feb;74(2):157-63
pubmed: 19755158
Peptides. 1998;19(4):777-80
pubmed: 9622035
Pharmacol Res. 2019 Mar;141:291-297
pubmed: 30616019
Recent Pat Drug Deliv Formul. 2009 Jan;3(1):71-89
pubmed: 19149731
Drug Deliv Transl Res. 2018 Feb;8(1):83-96
pubmed: 29134552
J Control Release. 2007 Feb 26;117(3):301-11
pubmed: 17239472
Curr Opin Investig Drugs. 2003 Dec;4(12):1416-21
pubmed: 14763126
Int J Pharm. 2009 Jul 6;376(1-2):104-9
pubmed: 19409469
CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66
pubmed: 17237035
J Control Release. 2009 Feb 20;134(1):55-61
pubmed: 19038299
Chem Rev. 2004 Dec;104(12):6147-76
pubmed: 15584698
J Neuroimmunol. 2004 Jun;151(1-2):66-77
pubmed: 15145605
Annu Rev Neurosci. 2003;26:81-104
pubmed: 12574495
Pharmacol Res. 2020 Jan;151:104551
pubmed: 31743776