Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases.
DNA
RNA
aging
cardiovascular disease
chronic disease
epigenetics
metabolism
nucleic acids
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Jan 2020
13 Jan 2020
Historique:
received:
14
11
2019
revised:
08
01
2020
accepted:
09
01
2020
entrez:
17
1
2020
pubmed:
17
1
2020
medline:
2
10
2020
Statut:
epublish
Résumé
RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes in RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging.
Identifiants
pubmed: 31941147
pii: ijms21020509
doi: 10.3390/ijms21020509
pmc: PMC7014325
pii:
doi:
Substances chimiques
RNA
63231-63-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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