Differential Roles of Mediodorsal Nucleus of the Thalamus and Prefrontal Cortex in Decision-Making and State Representation in a Cognitive Control Task Measuring Deficits in Schizophrenia.
MD thalamus
cognitive control
neurophysiology
prefrontal
primate
schizophrenia
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
19 02 2020
19 02 2020
Historique:
received:
16
07
2019
revised:
12
12
2019
accepted:
05
01
2020
pubmed:
17
1
2020
medline:
18
8
2020
entrez:
17
1
2020
Statut:
ppublish
Résumé
The mediodorsal nucleus of the thalamus (MD) is reciprocally connected with the prefrontal cortex (PFC), and although the MD has been implicated in a range of PFC-dependent cognitive functions (Watanabe and Funahashi, 2012; Mitchell and Chakraborty, 2013; Parnaudeau et al., 2018), little is known about how MD neurons in the primate participate specifically in cognitive control, a capability that reflects the ability to use contextual information (such as a rule) to modify responses to environmental stimuli. To learn how the MD-PFC thalamocortical network is engaged to mediate forms of cognitive control that are selectively disrupted in schizophrenia, we trained male monkeys to perform a variant of the AX continuous performance task, which reliably measures cognitive control deficits in patients (Henderson et al., 2012) and used linear multielectrode arrays to record neural activity in the MD and PFC simultaneously. We found that the two structures made clearly different contributions to distributed processing for cognitive control: MD neurons were specialized for decision-making and response selection, whereas prefrontal neurons were specialized to preferentially encode the environmental state on which the decision was based. In addition, we observed that functional coupling between MD and PFC was strongest when the decision as to which of the two responses in the task to execute was being made. These findings delineate unique contributions of MD and PFC to distributed processing for cognitive control and characterized neural dynamics in this network associated with normative cognitive control performance.
Identifiants
pubmed: 31941665
pii: JNEUROSCI.1703-19.2020
doi: 10.1523/JNEUROSCI.1703-19.2020
pmc: PMC7046322
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1650-1667Subventions
Organisme : NIMH NIH HHS
ID : F31 MH109238
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH119569
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107491
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 the authors.
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