Left ventricular mass index and subendocardial myocardial function in children with chronic kidney disease, a transmural strain and three-dimensional echocardiographic study.
chronic kidney disease
insulin resistance
left ventricular hypertrophy
subendocardial dysfunction
Journal
Cardiovascular endocrinology & metabolism
ISSN: 2574-0954
Titre abrégé: Cardiovasc Endocrinol Metab
Pays: United States
ID NLM: 101730894
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
03
07
2019
accepted:
30
09
2019
entrez:
17
1
2020
pubmed:
17
1
2020
medline:
17
1
2020
Statut:
epublish
Résumé
Left ventricular hypertrophy (LVH) is the commonest myocardial response to chronic kidney disease (CKD); this response has been regarded detrimental as it impairs the blood flow to the deepest layers of the myocardium causing progressive myocardial dysfunction. The aim of these series is to assess the determinants of LVH in CKD patients and its impact on subendocardial function in such patients. This study has been conducted on 40 CKD patients (Group 1) and 40 age-matched controls, both groups were assessed by transmural echocardiography to determine the subepicardial and subendocardial global longitudinal strain (GLS) as an expression of the systolic function of each of those layers. LVH was assessed by calculation of left ventricle mass index (LVMI). Both groups underwent ambulatory blood pressure monitoring. Group 1 was assessed as regards lipid profile and insulin resistance by homeostasis model assessment of insulin resistance (HOMA-IR). HOMA-IR proved to be a more important determinant of LV hypertrophy than SBP and DBP with a This study points toward the importance of insulin resistance in aggravation of myocardial remodeling in CKD patients; more studies are warranted to examine the role of insulin Sensitizers in reversing such remodeling and restoring subendocardial function in such important systemic disorder.
Identifiants
pubmed: 31942553
doi: 10.1097/XCE.0000000000000186
pmc: PMC6946150
doi:
Types de publication
Journal Article
Langues
eng
Pagination
115-118Informations de copyright
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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