I-Optimal Design of Hierarchical 3D Scaffolds Produced by Combining Additive Manufacturing and Thermally Induced Phase Separation.
3D plotting
additive manufacturing
bone tissue engineering
design of experiments (DoE)
macro/microporous scaffolds
thermally induced phase separation
Journal
ACS applied bio materials
ISSN: 2576-6422
Titre abrégé: ACS Appl Bio Mater
Pays: United States
ID NLM: 101729147
Informations de publication
Date de publication:
18 Feb 2019
18 Feb 2019
Historique:
entrez:
17
1
2020
pubmed:
17
1
2020
medline:
17
1
2020
Statut:
ppublish
Résumé
The limitations in the transport of oxygen, nutrients, and metabolic waste products pose a challenge to the development of bioengineered bone of clinically relevant size. This paper reports the design and characterization of hierarchical macro/microporous scaffolds made of poly(lactic-co-glycolic) acid and nanohydroxyapatite (PLGA/nHA). These scaffolds were produced by combining additive manufacturing (AM) and thermally induced phase separation (TIPS) techniques. Macrochannels with diameters of ~300 μm, ~380 μm, and ~460 μm were generated by embedding porous 3D-plotted polyethylene glycol (PEG) inside PLGA/nHA/1,4-dioxane or PLGA/1,4-dioxane solutions, followed by PEG extraction using deionized (DI) water. We have used an I-optimal design of experiments (DoE) and the response surface analysis (JMP® software) to relate three responses (scaffold thickness, porosity, and modulus) to the four experimental factors affecting the scaffold macro/microstructures (
Identifiants
pubmed: 31942566
doi: 10.1021/acsabm.8b00534
pmc: PMC6961819
mid: NIHMS1064124
doi:
Types de publication
Journal Article
Langues
eng
Pagination
685-696Subventions
Organisme : NIAMS NIH HHS
ID : R15 AR066269
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest Disclosure The authors declare no competing financial interest.
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