Activation of endogenous protein phosphatase 1 enhances the calcium sensitivity of the ryanodine receptor type 2 in murine ventricular cardiomyocytes.
Ca2+-induced Ca2+ release
cardiac muscle
de-phosphorylation
excitation-contraction coupling
protein phosphatase
ryanodine receptor 2
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
06
12
2019
accepted:
10
01
2020
pubmed:
17
1
2020
medline:
9
2
2021
entrez:
17
1
2020
Statut:
ppublish
Résumé
Increased protein phosphatase 1 (PP-1) activity has been found in end stage human heart failure. Although PP-1 has been extensively studied, a detailed understanding of its role in the excitation-contraction coupling mechanism, in normal and diseased hearts, remains elusive. The present study investigates the functional effect of the PP-1 activity on local Ca Changes in cardiac ryanodine receptor (RyR2) phosphorylation are considered to be important regulatory and disease related post-translational protein modifications. The extent of RyR2 phosphorylation is mainly determined by the balance of the activities of protein kinases and phosphatases, respectively. Increased protein phosphatase-1 (PP-1) activity has been observed in heart failure, although the regulatory role of this enzyme on intracellular Ca
Substances chimiques
Ryanodine Receptor Calcium Release Channel
0
Protein Phosphatase 1
EC 3.1.3.16
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1131-1150Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society.
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