Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Animals
Autophagy
Cell Membrane
/ metabolism
Endocytosis
Epithelial Cells
/ metabolism
ErbB Receptors
/ metabolism
Humans
Intracellular Signaling Peptides and Proteins
/ deficiency
Kidney Tubules, Proximal
/ metabolism
Lipid Metabolism
Lipidomics
Lysosomes
/ metabolism
Male
Mice
Mice, Knockout
Mice, Transgenic
Oxygen Consumption
Phospholipids
/ metabolism
Autophagic flux
RUBCN/Rubicon
autophagy
lipid efflux
lysosome
metabolic syndrome
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
17
1
2020
medline:
28
9
2021
entrez:
17
1
2020
Statut:
ppublish
Résumé
Macroautophagy/autophagy is a lysosomal degradation system which plays a protective role against kidney injury. RUBCN/Rubicon (RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein) inhibits the fusion of autophagosomes and lysosomes. However, its physiological role in kidney proximal tubular epithelial cells (PTECs) remains uncertain. In the current study, we analyzed the phenotype of newly generated PTEC-specific
Identifiants
pubmed: 31944172
doi: 10.1080/15548627.2020.1712107
pmc: PMC8386605
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Phospholipids
0
Rubcn protein, mouse
0
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1889-1904Références
Sci Signal. 2012 Jun 12;5(228):ra42
pubmed: 22692423
Biochim Biophys Acta Biomembr. 2017 Apr;1859(4):605-618
pubmed: 27693344
J Am Soc Nephrol. 2019 Jun;30(6):929-945
pubmed: 31040190
Diabetes. 2017 May;66(5):1359-1372
pubmed: 28246295
N Engl J Med. 2013 Feb 14;368(7):651-62
pubmed: 23406030
Autophagy. 2017 Mar 4;13(3):464-472
pubmed: 28055300
Cell Death Dis. 2016 Dec 22;7(12):e2527
pubmed: 28005078
Nat Cell Biol. 2009 Apr;11(4):385-96
pubmed: 19270696
Autophagy. 2018;14(1):53-65
pubmed: 29130363
Cell. 2012 Apr 13;149(2):274-93
pubmed: 22500797
Am J Pathol. 2003 Jul;163(1):313-20
pubmed: 12819036
PLoS One. 2014 Sep 02;9(9):e105787
pubmed: 25181357
J Cardiovasc Pharmacol. 2015 Mar;65(3):252-61
pubmed: 25502307
Mol Biol Cell. 2010 Dec;21(23):4162-72
pubmed: 20943950
J Biol Chem. 1957 May;226(1):497-509
pubmed: 13428781
Nature. 2008 Feb 28;451(7182):1069-75
pubmed: 18305538
Mol Cell. 2015 Jan 22;57(2):207-18
pubmed: 25533187
Autophagy. 2016;12(1):1-222
pubmed: 26799652
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):817-22
pubmed: 10639163
Hepatology. 2016 Dec;64(6):1994-2014
pubmed: 27637015
Mutat Res. 2011 Jun 3;711(1-2):158-66
pubmed: 21419786
J Lipid Res. 2010 Jul;51(7):1719-28
pubmed: 19965614
Dev Cell. 2015 Mar 23;32(6):678-92
pubmed: 25752962
J Am Soc Nephrol. 2011 May;22(5):902-13
pubmed: 21493778
J Biol Chem. 1997 Oct 31;272(44):28142-8
pubmed: 9346970
Autophagy. 2016 May 3;12(5):801-13
pubmed: 26986194
Science. 2017 Mar 24;355(6331):1306-1311
pubmed: 28336668
Curr Opin Nephrol Hypertens. 2010 Jul;19(4):393-402
pubmed: 20489613
Am J Pathol. 2012 Feb;180(2):517-25
pubmed: 22265049
FEBS Lett. 2000 Mar 31;470(3):263-8
pubmed: 10745079
Mol Biol Cell. 2004 Mar;15(3):1101-11
pubmed: 14699058
Nat Cell Biol. 2009 Apr;11(4):468-76
pubmed: 19270693
Curr Biol. 2013 Aug 5;23(15):1489-96
pubmed: 23871243
J Lipid Res. 2018 Jul;59(7):1283-1293
pubmed: 29724780
J Am Soc Nephrol. 2017 May;28(5):1534-1551
pubmed: 27932476
Nature. 1999 Dec 9;402(6762):672-6
pubmed: 10604474
Am J Physiol. 1988 Nov;255(5 Pt 2):F977-83
pubmed: 2847554
Autophagy. 2017 Oct 3;13(10):1629-1647
pubmed: 28813167