Multipoint dilution hemofiltration: A new technology for maximum convective clearance.
dialysis
dialyzer
hemodiafiltration
hemodialysis
hemofiltration
Journal
Artificial organs
ISSN: 1525-1594
Titre abrégé: Artif Organs
Pays: United States
ID NLM: 7802778
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
21
11
2019
revised:
06
01
2020
accepted:
10
01
2020
pubmed:
17
1
2020
medline:
13
4
2021
entrez:
17
1
2020
Statut:
ppublish
Résumé
Convection-based renal replacement therapies (RRTs) have the potential to improve patient outcomes when compared to diffusion-based RRT such as hemodialysis (HD), but have limited clearance rates. We propose and characterize multipoint dilution hemofiltration (MPD-HF), a purely convective blood purification technology which removes the fundamental filtration limit associated with convective RRT resulting in clearance rates on par with HD. In MPD-HF, filtration of liquid and solutes occurs along the length of the hollow fibers that convey the blood, and substitution fluid is pushed into the fibers at multiple points along their length. Since multiple filtration and dilution steps are contained within one pass of the blood through the hollow fiber, the fraction of fluid that can be filtered may be increased to allow a high clearance rate that removes a wide range of toxins. In vitro tests yielded an average steady-state filtrate fraction of 68%, exceeding commercial HDF cartridge filtrate fractions by a factor of approximately 3. The molecular weights of molecules cleared spans up to the cutoff of 66 kDa for albumin.
Substances chimiques
Dialysis Solutions
0
Toxins, Biological
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
753-763Subventions
Organisme : Charles Stark Draper Laboratory
Informations de copyright
© 2020 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
Références
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