An Air-Stable, Neutral Phenothiazinyl Radical with Substantial Radical Stabilization Energy.
aminyl radicals
phenothiazines
radical stabilization energy
radicals
redox chemistry
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
09 Mar 2020
09 Mar 2020
Historique:
received:
19
11
2019
pubmed:
17
1
2020
medline:
17
1
2020
entrez:
17
1
2020
Statut:
ppublish
Résumé
The vital effect of radical states on the pharmacological activity of phenothiazine-based drugs has long been speculated. Whereas cationic radicals of N-substituted phenothiazines show high stability, the respective neutral radicals of N-unsubstituted phenothiazines have never been isolated. Herein, the 1,9-diamino-3,7-di-tert-butyl-N
Identifiants
pubmed: 31944465
doi: 10.1002/chem.201905238
pmc: PMC7079145
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3152-3156Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GR 5007/2-1
Informations de copyright
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
Références
Chemistry. 2018 Aug 14;24(46):11936-11943
pubmed: 29766577
Biochem J. 1968 Jan;106(1):155-60
pubmed: 4388686
Chemistry. 2020 Mar 9;26(14):3152-3156
pubmed: 31944465
Psychosomatics. 2010 May-Jun;51(3):194-200
pubmed: 20484716
Eur J Med Chem. 2011 Aug;46(8):3179-89
pubmed: 21620536
Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9434-9438
pubmed: 29882340
J Am Chem Soc. 2018 Apr 18;140(15):5290-5299
pubmed: 29589754
Chem Commun (Camb). 2019 Apr 9;55(30):4371-4374
pubmed: 30912541
J Am Chem Soc. 2014 Aug 27;136(34):11906-9
pubmed: 25093450
Chem Rev. 2017 Nov 8;117(21):13230-13319
pubmed: 28991454
J Anaesthesiol Clin Pharmacol. 2010 Oct;26(4):517-20
pubmed: 21547182
Chem Soc Rev. 2013 Feb 21;42(4):1440-59
pubmed: 22975722
Org Biomol Chem. 2015 Jan 7;13(1):157-69
pubmed: 25351112
J Am Chem Soc. 2004 Feb 11;126(5):1388-401
pubmed: 14759197
Am J Ther. 2003 Jul-Aug;10(4):289-91
pubmed: 12845393
Am J Ther. 2006 May-Jun;13(3):261-73
pubmed: 16772768
Photosynth Res. 2009 Nov-Dec;102(2-3):377-90
pubmed: 19728138
J Am Chem Soc. 2012 Jul 18;134(28):11330-3
pubmed: 22746974
Angew Chem Int Ed Engl. 2019 Jun 3;58(23):7850-7855
pubmed: 30945403
Angew Chem Int Ed Engl. 2015 Mar 23;54(13):4102-4
pubmed: 25655504
J Chemother. 2002 Oct;14(5):431-43
pubmed: 12462423
Chem Commun (Camb). 2015 Jul 28;51(59):11822-5
pubmed: 26108703
Angew Chem Int Ed Engl. 2018 Mar 26;57(14):3733-3736
pubmed: 29442422
Nat Commun. 2017 May 15;8:15088
pubmed: 28504260
J Emerg Med. 2014 May;46(5):670-9
pubmed: 24508113
Chem Commun (Camb). 2015 Jan 31;51(9):1553-4
pubmed: 25532850
Anticancer Res. 2017 Nov;37(11):5983-5993
pubmed: 29061777
Chemistry. 2016 Jan 11;22(2):663-71
pubmed: 26616833
Org Lett. 2004 Sep 30;6(20):3493-6
pubmed: 15387531
Science. 1939 Nov 3;90(2340):422-3
pubmed: 17834134
Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7435-7439
pubmed: 28485120
Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13758-63
pubmed: 26404498
J Am Chem Soc. 2001 Sep 19;123(37):9112-8
pubmed: 11552819