Physicochemical Characteristics of Platelet Factor 4 under Various Conditions are Relevant for Heparin-Induced Thrombocytopenia Testing.


Journal

The journal of physical chemistry. B
ISSN: 1520-5207
Titre abrégé: J Phys Chem B
Pays: United States
ID NLM: 101157530

Informations de publication

Date de publication:
27 02 2020
Historique:
pubmed: 17 1 2020
medline: 30 3 2021
entrez: 17 1 2020
Statut: ppublish

Résumé

Heparin-induced thrombocytopenia (HIT), an adverse drug effect, has gained much attention. Affected patients have a high risk of new thrombotic complications. In addition, HIT is also a model to study mechanisms of immune-mediated disorders. Platelet factor 4 (PF4) is the key protein involved. It is the basis for many diagnostic tests for HIT and is used for

Identifiants

pubmed: 31944769
doi: 10.1021/acs.jpcb.9b11695
doi:

Substances chimiques

PF4 protein, human 0
Platelet Factor 4 37270-94-3
Heparin 9005-49-6
Magnesium I38ZP9992A
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1438-1443

Commentaires et corrections

Type : ErratumIn

Auteurs

Van-Chien Bui (VC)

Institute for Immunology and Transfusion Medicine , University Medicine of Greifswald , 17475 Greifswald , Mecklenburg-Vorpommern , Germany.

Patrycja Gebicka (P)

Institute for Immunology and Transfusion Medicine , University Medicine of Greifswald , 17475 Greifswald , Mecklenburg-Vorpommern , Germany.
Chromatec , 17489 Greifswald , Mecklenburg-Vorpommern , Germany.

Holger Hippe (H)

Chromatec , 17489 Greifswald , Mecklenburg-Vorpommern , Germany.

Ricarda Raschke (R)

Institute for Immunology and Transfusion Medicine , University Medicine of Greifswald , 17475 Greifswald , Mecklenburg-Vorpommern , Germany.

Thuy-Linh Nguyen (TL)

Institute for Immunology and Transfusion Medicine , University Medicine of Greifswald , 17475 Greifswald , Mecklenburg-Vorpommern , Germany.

Andreas Greinacher (A)

Institute for Immunology and Transfusion Medicine , University Medicine of Greifswald , 17475 Greifswald , Mecklenburg-Vorpommern , Germany.

Thi-Huong Nguyen (TH)

Institute for Immunology and Transfusion Medicine , University Medicine of Greifswald , 17475 Greifswald , Mecklenburg-Vorpommern , Germany.
Institute for Bioprocessing and Analytical Measurement Techniques , Rosenhof D , 37308 Heilbad Heiligenstadt , Thuringia , Germany.

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Classifications MeSH