Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population.
case-control study
colorectal cancer
hepatitis B virus
population-based
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
14 01 2020
14 01 2020
Historique:
received:
13
12
2019
revised:
07
01
2020
accepted:
10
01
2020
entrez:
18
1
2020
pubmed:
18
1
2020
medline:
9
2
2021
Statut:
epublish
Résumé
Chronic hepatitis B virus (HBV) infections and colorectal cancer (CRC) are prevalent in Taiwan. We carried out a population-based case-control study to assess the association between HBV infection and CRC risk. Using the National Health Insurance Research Database of Taiwan, we identified 69,478 newly diagnosed patients with CRC from 2005 to 2011. We further randomly selected 69,478 age- and gender-matched controls without CRC from the same database. Odds ratios (ORs) were calculated to evaluate the association between chronic HBV infection and CRC using a logistic regression analysis. HBV infection was found to be associated with the risk of CRC (OR = 1.27, 95% confidence interval (CI) = 1.20-1.33). This relationship was similar in men and women. Age-specific analysis revealed that the CRC risk associated with HBV decreased with age. The adjusted ORs for patients aged <55, 55-64, and 65-74 years were 1.63 (95% CI = 1.48-1.79), 1.24 (95% CI = 1.13-1.37), and 1.02 (95% = 0.92-1.13), respectively. In conclusion, this study suggests that chronic HBV infection is significantly associated with an increased risk of CRC. Monitoring the risk of CRC development in young patients with HBV infection is crucial.
Identifiants
pubmed: 31947702
pii: v12010097
doi: 10.3390/v12010097
pmc: PMC7019239
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors have no competing interests to declare.
Références
East Afr Med J. 1995 Jul;72(7):424-6
pubmed: 7498023
Hepatobiliary Pancreat Dis Int. 2004 May;3(2):223-5
pubmed: 15138114
Am J Gastroenterol. 2019 Feb;114(2):322-329
pubmed: 30694865
Hepatology. 1993 Oct;18(4):781-9
pubmed: 8406351
PeerJ. 2018 Feb 16;6:e4297
pubmed: 29472994
J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:144-52
pubmed: 21199526
Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11135-40
pubmed: 15258290
Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):792-7
pubmed: 16614125
Semin Fetal Neonatal Med. 2007 Jun;12(3):160-7
pubmed: 17336170
Semin Liver Dis. 1984 May;4(2):113-21
pubmed: 6087457
Lancet Oncol. 2010 Sep;11(9):827-34
pubmed: 20688564
Liver Int. 2010 Mar;30(3):423-9
pubmed: 19840258
Microb Pathog. 2019 Mar;128:184-194
pubmed: 30611768
Gastroenterol Jpn. 1984 Aug;19(4):363-6
pubmed: 6489693
Am J Gastroenterol. 2005 Mar;100(3):515-23; discussion 514
pubmed: 15743345
Mol Cell Biol. 2013 Aug;33(15):2810-6
pubmed: 23716588
Med Mol Morphol. 2009 Sep;42(3):138-42
pubmed: 19784739
J Gastrointest Oncol. 2015 Oct;6(5):492-7
pubmed: 26487942
Transfusion. 2012 Aug;52(8):1819-26
pubmed: 22404554
Nat Commun. 2016 Oct 05;7:12992
pubmed: 27703150
Semin Oncol. 2014 Dec;41(6):860-75
pubmed: 25499643
J Hepatol. 2016 Apr;64(1 Suppl):S84-S101
pubmed: 27084040
Br J Cancer. 2015 Mar 31;112(7):1283-90
pubmed: 25695484
Nat Genet. 2012 May 27;44(7):765-9
pubmed: 22634754
Nat Rev Dis Primers. 2015 Nov 05;1:15065
pubmed: 27189416
Clin Gastroenterol Hepatol. 2014 May;12(5):738-48
pubmed: 23811241
J Gen Virol. 1984 Mar;65 ( Pt 3):651-5
pubmed: 6699625
Lancet Oncol. 2005 Nov;6(11):871-6
pubmed: 16257795
World J Gastroenterol. 2014 Aug 14;20(30):10238-48
pubmed: 25132741
BMC Cancer. 2011 Nov 24;11:495
pubmed: 22115285
JAMA Netw Open. 2019 Jun 5;2(6):e195718
pubmed: 31199446
Am J Med Sci. 2018 Aug;356(2):141-146
pubmed: 30219156
J Gen Virol. 2015 Aug;96(8):2242-2251
pubmed: 25872745
Hepatology. 2011 Apr;53(4):1217-25
pubmed: 21480326
CA Cancer J Clin. 2015 Mar;65(2):87-108
pubmed: 25651787