8-Oxo-7,8-Dihydro-2'-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2'-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development.
8-hydroxy-2′-deoxyguanosine
8-oxo-7,8-dihydro-2′-deoxyguanosine
DNA damage
gestational diabetes mellitus
oxidative stress
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
03 Jan 2020
03 Jan 2020
Historique:
received:
22
11
2019
revised:
30
12
2019
accepted:
01
01
2020
entrez:
18
1
2020
pubmed:
18
1
2020
medline:
8
10
2020
Statut:
epublish
Résumé
The growing clinical and epidemiological significance of gestational diabetes mellitus results from its constantly increasing worldwide prevalence, obesity, and overall unhealthy lifestyle among women of childbearing age. Oxidative stress seems to be the most important predictor of gestational diabetes mellitus development. Disturbances in the cell caused by oxidative stress lead to different changes in biomolecules, including DNA. The nucleobase which is most susceptible to oxidative stress is guanine. Its damage results in two main modifications: 8-hydroxy-2'-deoxyguanosineor 8-oxo-7,8-dihydro-2'-deoxyguanosine. Their significant level can indicate pathological processes during pregnancy, like gestational diabetes mellitus and probably, type 2 diabetes mellitus after pregnancy. This review provides an overview of current knowledge on the use of 8-hydroxy-2'-deoxyguanosineand/or 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker in gestational diabetes mellitus and allows us to understand the mechanism of 8-hydroxy-2'-deoxyguanosineand/or 8-oxo-7,8-dihydro-2'-deoxyguanosine generation during this disease.
Identifiants
pubmed: 31947819
pii: molecules25010202
doi: 10.3390/molecules25010202
pmc: PMC6982778
pii:
doi:
Substances chimiques
Biomarkers
0
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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