Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults.

Hyperglycemia is linked to impaired arterial endothelial function (EF), an early sign of cardiovascular disease. We compared the efficacy of low-glycemic index isomaltulose (Palatinose™) with that of sucrose in modulating EF, as assessed by flow-mediated dilation (FMD). In this double-blinded cross-over study, 80 overweight mildly hypertensive subjects were randomized to receive 50 g of either isomaltulose or sucrose. On two non-consecutive days, brachial artery ultrasound FMD scans were obtained prior to and hourly (T0-T3) after carbohydrate load. Blood was drawn immediately after scanning. Glucose and insulin levels were analyzed. Overall, the FMD decrease was attenuated by isomaltulose compared to sucrose (ΔFMD = -0.003% and -0.151%;

Déclaration de conflit d'intérêts

E.d.G. has honorary consultancies with Atlantia Food CRO, COLSWE environmental sensors, AiREAS corporation and Municipality of Eindhoven, and the Departments of Clinical Epidemiology, Biostatistics and Bioinformatics, and Gastroenterolog, of the Amsterdam UMC—Academic Medical Centre. E.d.G. receives writing fees from Up-to-Date in Cardiology (Wolters Kluwer). E.d.G. is owner and employee of Imagelabonline & Cardiovascular. Imagelabonline served as a subcontractor for Atlantia Food CRO, Cork, Ireland in the present study. E.d.G. also received research grants from the AMC Research Foundation, Academic Medical Center—Amsterdam UMC, Bioactor BV, Pfizer, LSP-Quartz, and the Municipality of Eindhoven. Otherwise, E.d.G. has no disclosures to make. S.T. and L.S. are employees of BENEO GmbH/Südzucker Group. In this double-blinded study, source data were provided by Atlantia Food Clinical Trials CRO, Cork, Ireland. Primary data analysis and report generation were undertaken by Atlantia Food Clinical Trials CRO independently from the sponsor. The statistical analyses of this publication have been developed for BENEO GmbH, which was also the exclusive sponsor of the project. BENEO GmbH reserves the exclusive right to use the results and data for possible Health Claim requests.