Critical redundant functions of the adapters Grb2 and Gads in platelet (hem)ITAM signaling in mice.

Adaptor Proteins, Signal Transducing / metabolism Animals GRB2 Adaptor Protein / metabolism Humans Immunoreceptor Tyrosine-Based Activation Motif / genetics Mice Signal Transduction
Adapter proteins ITAM hemostasis mice signaling

Journal

Platelets
ISSN: 1369-1635
Titre abrégé: Platelets
Pays: England
ID NLM: 9208117

Informations de publication

Date de publication:
17 Aug 2020
Historique:
pubmed: 18 1 2020
medline: 29 5 2021
entrez: 18 1 2020
Statut: ppublish

Résumé

Platelets are essential for normal hemostasis; however, pathological conditions can also trigger unwanted platelet activation precipitating thrombosis and ischemic damage of vital organs such as the heart or brain.

Identifiants

DOI: 10.1080/09537104.2019.1709633 PMID: 31948362
pubmed: 31948362
doi: 10.1080/09537104.2019.1709633
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
GRB2 Adaptor Protein 0
Grb2 protein, mouse 0
Mona protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

801-811

Subventions

Organisme : British Heart Foundation
ID : CH/03/003/15571
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/13/18/30563
Pays : United Kingdom

Auteurs

Timo Vögtle (T)

Institute of Experimental Biomedicine I, University Hospital Würzburg and Rudolf Virchow Center, University of Würzburg , Würzburg, Germany.
ORCID: 0000-0002-9400-4701

Ayesha A Baig (AA)

Institute of Experimental Biomedicine I, University Hospital Würzburg and Rudolf Virchow Center, University of Würzburg , Würzburg, Germany.

Julia Volz (J)

Institute of Experimental Biomedicine I, University Hospital Würzburg and Rudolf Virchow Center, University of Würzburg , Würzburg, Germany.

Timothy B Duchow (TB)

Institute of Experimental Biomedicine I, University Hospital Würzburg and Rudolf Virchow Center, University of Würzburg , Würzburg, Germany.

Irina Pleines (I)

Institute of Experimental Biomedicine I, University Hospital Würzburg and Rudolf Virchow Center, University of Würzburg , Würzburg, Germany.
ORCID: 0000-0002-9959-8174

Sebastian Dütting (S)

Institute of Experimental Biomedicine I, University Hospital Würzburg and Rudolf Virchow Center, University of Würzburg , Würzburg, Germany.

Lars Nitschke (L)

Department of Biology, Division of Genetics, University of Erlangen , Erlangen, Germany.

Stephen P Watson (SP)

Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham , The Midlands, UK.
ORCID: 0000-0002-7846-7423

Bernhard Nieswandt (B)

Institute of Experimental Biomedicine I, University Hospital Würzburg and Rudolf Virchow Center, University of Würzburg , Würzburg, Germany.
ORCID: 0000-0003-1454-7413

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Critical redundant functions of the adapters...
questionsmedicales.fr › Eucaryotes › Animaux › Critical redundant functions of the adapters...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéine adaptatrice GRB2 › Critical redundant functions of the adapters...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Critical redundant functions of the adapters...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Motif d'activation de l'immunorécepteur dépendant de la tyrosine › Critical redundant functions of the adapters...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Critical redundant functions of the adapters...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Critical redundant functions of the adapters...