The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells.
Calpains
Calpastatin
ERG1A
Intracellular calcium
Skeletal muscle atrophy
Journal
Skeletal muscle
ISSN: 2044-5040
Titre abrégé: Skelet Muscle
Pays: England
ID NLM: 101561193
Informations de publication
Date de publication:
16 01 2020
16 01 2020
Historique:
received:
04
06
2019
accepted:
18
12
2019
entrez:
18
1
2020
pubmed:
18
1
2020
medline:
29
7
2021
Statut:
epublish
Résumé
Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvation, and normal aging. Currently, there is no truly effective pharmacological therapy for atrophy; therefore, exploration of the mechanisms contributing to atrophy is essential because it will eventually lead to discovery of an effective therapeutic target. The ether-a-go-go related gene (ERG1A) K We transduced C Expression of human ERG1A in C Human ERG1A expression increases both intracellular calcium concentration and combined calpain 1 and 2 activity. The increased calpain activity is likely a result of the increased calcium levels and decreased calpastatin abundance.
Sections du résumé
BACKGROUND
Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvation, and normal aging. Currently, there is no truly effective pharmacological therapy for atrophy; therefore, exploration of the mechanisms contributing to atrophy is essential because it will eventually lead to discovery of an effective therapeutic target. The ether-a-go-go related gene (ERG1A) K
METHODS
We transduced C
RESULTS
Expression of human ERG1A in C
CONCLUSIONS
Human ERG1A expression increases both intracellular calcium concentration and combined calpain 1 and 2 activity. The increased calpain activity is likely a result of the increased calcium levels and decreased calpastatin abundance.
Identifiants
pubmed: 31948476
doi: 10.1186/s13395-019-0220-3
pii: 10.1186/s13395-019-0220-3
pmc: PMC6966811
doi:
Substances chimiques
Calcium-Binding Proteins
0
ERG1 Potassium Channel
0
calpastatin
79079-11-1
Calpain
EC 3.4.22.-
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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