The Peril and Promise of Integrons: Beyond Antibiotic Resistance.
biotechnology
evolution
pathogenicity
synthetic biology
virulence
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
21
08
2019
revised:
13
11
2019
accepted:
09
12
2019
pubmed:
18
1
2020
medline:
26
5
2021
entrez:
18
1
2020
Statut:
ppublish
Résumé
Integrons are bacterial genetic elements that can capture, rearrange, and express mobile gene cassettes. They are best known for their role in disseminating antibiotic-resistance genes among pathogens. Their ability to rapidly spread resistance phenotypes makes it important to consider what other integron-mediated traits might impact human health in the future, such as increased virulence, pathogenicity, or resistance to novel antimicrobial strategies. Exploring the functional diversity of cassettes and understanding their de novo creation will allow better pre-emptive management of bacterial growth, while also facilitating development of technologies that could harness integron activity. If we can control integrons and cassette formation, we could use integrons as a platform for enzyme discovery and to construct novel biochemical pathways, with applications in bioremediation or biosynthesis of industrial and therapeutic molecules. Integron activity thus holds both peril and promise for humans.
Identifiants
pubmed: 31948729
pii: S0966-842X(19)30317-8
doi: 10.1016/j.tim.2019.12.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-464Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.