Anterior segment optical coherence tomographic characterisation of keratic precipitates.
Anterior segment optical coherence tomography
Cornea
Keratic precipitates
Journal
Contact lens & anterior eye : the journal of the British Contact Lens Association
ISSN: 1476-5411
Titre abrégé: Cont Lens Anterior Eye
Pays: England
ID NLM: 9712714
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
11
09
2019
revised:
20
12
2019
accepted:
05
01
2020
pubmed:
18
1
2020
medline:
1
9
2021
entrez:
18
1
2020
Statut:
ppublish
Résumé
Anterior segment optical coherence tomography (AS-OCT) can be used to visualise keratic precipitates (KPs) on the corneal endothelium. However, there has been no correlation between characteristic clinical appearances of KPs and AS-OCT morphology. We wished to assess the potential diagnostic role of AS-OCT in patients presenting with inflammatory eye disease and KPs. Six patients with inflammatory KPs were compared to one patient with infective interface keratitis following Descemet Membrane Endothelial Keratoplasty (DMEK) and one patient with endothelial pigment. AS-OCT was performed in each case and morphological features of the KPs were compared. Reflectivity of KPs was also compared numerically by measuring their relative lightness. AS-OCT images in acute and active inflammation generally demonstrated hyperreflective KP variants in comparison to conditions with moderate or longstanding inflammation. In the patient with infective interface keratitis, KPs were evident on the endothelial surface but no changes could be identified at the graft-host interface. There were no significant differences between infective and inflammatory KPs to help distinguish between the two. Endothelial pigment deposits were clearly differentiated from keratic precipitates with smaller, poorly defined deposits on the endothelium surface which were isoreflective to the cornea. Hyperreflective KPs could be suggestive of newly deposited KPs and active inflammation; they may also be increased in KPs of herpetic origin. AS-OCT should not be used to differentiate infective infiltrate from inflammatory KPs if a patient were to present with post-operative inflammation and interface infection should still be suspected even if only endothelial deposits are identified on AS-OCT. AS-OCT may be used as a diagnostic and monitoring tool to assess response to treatment in cases where anterior segment inflammation of uncertain aetiology is present.
Sections du résumé
BACKGROUND/OBJECTIVES
Anterior segment optical coherence tomography (AS-OCT) can be used to visualise keratic precipitates (KPs) on the corneal endothelium. However, there has been no correlation between characteristic clinical appearances of KPs and AS-OCT morphology. We wished to assess the potential diagnostic role of AS-OCT in patients presenting with inflammatory eye disease and KPs.
SUBJECTS/METHODS
Six patients with inflammatory KPs were compared to one patient with infective interface keratitis following Descemet Membrane Endothelial Keratoplasty (DMEK) and one patient with endothelial pigment. AS-OCT was performed in each case and morphological features of the KPs were compared. Reflectivity of KPs was also compared numerically by measuring their relative lightness.
RESULTS
AS-OCT images in acute and active inflammation generally demonstrated hyperreflective KP variants in comparison to conditions with moderate or longstanding inflammation. In the patient with infective interface keratitis, KPs were evident on the endothelial surface but no changes could be identified at the graft-host interface. There were no significant differences between infective and inflammatory KPs to help distinguish between the two. Endothelial pigment deposits were clearly differentiated from keratic precipitates with smaller, poorly defined deposits on the endothelium surface which were isoreflective to the cornea.
CONCLUSION
Hyperreflective KPs could be suggestive of newly deposited KPs and active inflammation; they may also be increased in KPs of herpetic origin. AS-OCT should not be used to differentiate infective infiltrate from inflammatory KPs if a patient were to present with post-operative inflammation and interface infection should still be suspected even if only endothelial deposits are identified on AS-OCT. AS-OCT may be used as a diagnostic and monitoring tool to assess response to treatment in cases where anterior segment inflammation of uncertain aetiology is present.
Identifiants
pubmed: 31948875
pii: S1367-0484(20)30003-5
doi: 10.1016/j.clae.2020.01.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
465-468Informations de copyright
Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.