Role of ADC values in assessing clinical response and identifying residual disease post-chemo radiation in uterine cervix cancer.
Apparent diffusion coefficient values
biomarker
fluoro-deoxy glucose positron-emission computed tomography
response assessment
uterine cervix
Journal
The Indian journal of radiology & imaging
ISSN: 0971-3026
Titre abrégé: Indian J Radiol Imaging
Pays: Germany
ID NLM: 8503873
Informations de publication
Date de publication:
Historique:
received:
10
08
2019
revised:
08
10
2019
accepted:
26
11
2019
entrez:
18
1
2020
pubmed:
18
1
2020
medline:
18
1
2020
Statut:
ppublish
Résumé
To evaluate the role of apparent diffusion coefficient (ADC) values in assessing response after chemo-radiotherapy in cervix cancer and investigate the utility of ADC as a tool to identify residual disease, after the treatment completion. A prospective study was done in 100 patients with histopathologically proven cancer of uterine cervix who were classified as either complete response (CR) or residual disease posttreatment. MRI was done pretreatment and after 6 weeks post-treatment with chemo-radiation. 53 patients among the cohort also underwent a fluoro-deoxy glucose positron-emission computed tomography (FDG-PET CT). ADC values, change in ADC values, and metabolic activity obtained from FDG-PET CT were correlated with clinical outcome, and statistical analysis was done to determine the better tool for assessing response evaluation between ADC and PET-CT. Residual lesions have notably lower ADC value than that of posttreatment changes. The mean ADC values of residual tumors: 1.26 ± 0.238 × 10 Diffusion imaging differentiates residual cervix malignancies from post treatment changes based on ADC values and can be a promising and evocative biomarker. Complimentary use of ADC and PET/CT may increase diagnostic confidence.
Identifiants
pubmed: 31949343
doi: 10.4103/ijri.IJRI_339_19
pii: IJRI-29-404
pmc: PMC6958886
doi:
Types de publication
Journal Article
Langues
eng
Pagination
404-411Informations de copyright
Copyright: © 2019 Indian Journal of Radiology and Imaging.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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