Polymorph evolution during crystal growth studied by 3D electron diffraction.
3DED
cryoTEM
crystallization
electron diffraction
glycine
polymorphism
Journal
IUCrJ
ISSN: 2052-2525
Titre abrégé: IUCrJ
Pays: England
ID NLM: 101623101
Informations de publication
Date de publication:
01 Jan 2020
01 Jan 2020
Historique:
received:
23
08
2019
accepted:
29
11
2019
entrez:
18
1
2020
pubmed:
18
1
2020
medline:
18
1
2020
Statut:
epublish
Résumé
3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 min, but this begins to yield the α-form after only 1 min more. Both structures could be determined from continuous rotation electron diffraction data collected in less than 20 s on crystals of thickness ∼100 nm. Even though the γ-form is thermodynamically the most stable polymorph, kinetics favour the α-form, which dominates after prolonged standing. In the same sample, some β and one crystallite of the γ polymorph were also observed.
Identifiants
pubmed: 31949899
doi: 10.1107/S2052252519016105
pii: yc5021
pmc: PMC6949601
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5-9Informations de copyright
© Broadhurst et al. 2020.
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