Exposure to Trichloroethylene Metabolite

AMP-Activated Protein Kinases / metabolism Amino Acids / metabolism Cell Line Cell Survival / drug effects Cysteine / analogs & derivatives Energy Metabolism / drug effects Glucose / metabolism Glycerol / metabolism Humans Lipid Metabolism / drug effects Nutrients / metabolism Phosphofructokinase-1 / metabolism Solvents / metabolism Trichloroethylene / metabolism

Journal

Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448

Informations de publication

Date de publication:
15 06 2020
Historique:
pubmed: 18 1 2020
medline: 8 7 2021
entrez: 18 1 2020
Statut: ppublish

Résumé

Trichloroethylene (TCE) is a widespread environmental contaminant following decades of use as an industrial solvent, improper disposal, and remediation challenges. Consequently, TCE exposure continues to constitute a risk to human health. Despite epidemiological evidence associating exposure with adverse birth outcomes, the effects of TCE and its metabolite

Identifiants

DOI: 10.1021/acs.chemrestox.9b00356 PMID: 31951115 PMC: PMC7299793
pubmed: 31951115
doi: 10.1021/acs.chemrestox.9b00356
pmc: PMC7299793
mid: NIHMS1552113
doi:

Substances chimiques

Amino Acids 0
Solvents 0
Trichloroethylene 290YE8AR51
S-(1,2-dichlorovinyl)cysteine 627-72-5
Phosphofructokinase-1 EC 2.7.1.11
AMP-Activated Protein Kinases EC 2.7.11.31
PRKAA1 protein, human EC 2.7.11.31
Glucose IY9XDZ35W2
Cysteine K848JZ4886
Glycerol PDC6A3C0OX

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1339-1355

Subventions

Organisme : NIEHS NIH HHS
ID : P42 ES017198
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK089503
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107535
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002240
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007062
Pays : United States

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Auteurs

Elana R Elkin (ER)

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109-2029, United States.
ORCID: 0000-0001-8637-1731

Dave Bridges (D)

Department of Nutritional Sciences, University of Michigan, Ann Arbor, Michigan 48109-2029, United States.

Sean M Harris (SM)

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109-2029, United States.

Rita Karen Loch-Caruso (RK)

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109-2029, United States.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-Activated Protein Kinases › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Glucides › Polyols › Dérivés du glycérol › Glycérol › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Aliments et boissons › Aliments › Nutriments › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Fructokinases › Phosphofructokinases › Phosphofructokinase-1 › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Exposure to Trichloroethylene Metabolite
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › Trichloroéthylène › Exposure to Trichloroethylene Metabolite