Bioengineered 3D Models to Recapitulate Tissue Fibrosis.
biofabrication
fibrosis
screening
self-assembly
tissue models
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
27
09
2019
revised:
05
12
2019
accepted:
06
12
2019
pubmed:
19
1
2020
medline:
20
7
2021
entrez:
19
1
2020
Statut:
ppublish
Résumé
Fibrosis, characterized by progressive tissue stiffening resulting in organ failure, is a growing health problem affecting millions of people worldwide. Currently, therapeutic options for tissue fibrosis are severely limited and organ transplantation is the only effective treatment for the end-stage fibrotic diseases with inherent limitations. Recent advancements in engineered 3D in vitro human disease mimic models, recapitulating the tissue pathophysiology, have provided unique state-of-the-art platforms for: (i) understanding the biological mechanisms involved in the disease pathogenesis; and (ii) high-throughput and reproducible drug screening. This review focuses on the recent multidisciplinary developments made towards advanced 3D biomimetic fibrotic tissue (liver, kidney, and lung) models that combine highly precision manufacturing techniques with high cellular functionality and biophysical (mechanical) properties.
Identifiants
pubmed: 31952833
pii: S0167-7799(19)30305-1
doi: 10.1016/j.tibtech.2019.12.010
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
623-636Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.