Background calcium induced by subthreshold depolarization modifies homosynaptic facilitation at a synapse in Aplysia.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 01 2020
17 01 2020
Historique:
received:
25
09
2019
accepted:
27
12
2019
entrez:
19
1
2020
pubmed:
19
1
2020
medline:
12
11
2020
Statut:
epublish
Résumé
Some synapses show two forms of short-term plasticity, homosynaptic facilitation, and a plasticity in which the efficacy of transmission is modified by subthreshold changes in the holding potential of the presynaptic neuron. In a previous study we demonstrated a further interactive effect. We showed that depolarizing changes in the presynaptic holding potential can increase the rate at which facilitation occurs. These experiments studied synaptic transmission between an Aplysia sensory neuron (B21) and its postsynaptic follower, the motor neuron (B8). We have also shown that subthreshold depolarizations of B21 produce widespread increases in its [Ca
Identifiants
pubmed: 31953443
doi: 10.1038/s41598-019-57362-2
pii: 10.1038/s41598-019-57362-2
pmc: PMC6969054
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
549Subventions
Organisme : NINDS NIH HHS
ID : R01 NS066587
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS070583
Pays : United States
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