Kaposi sarcoma among people living with HIV in the French DAT'AIDS cohort between 2010 and 2015.

Acquired Immunodeficiency Syndrome HIV Infections / complications Herpesvirus 8, Human Humans Retrospective Studies Sarcoma, Kaposi / epidemiology

Journal

Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037

Informations de publication

Date de publication:
May 2020
Historique:
received: 12 09 2019
accepted: 17 12 2019
pubmed: 19 1 2020
medline: 15 5 2021
entrez: 19 1 2020
Statut: ppublish

Résumé

Although antiretroviral therapy (ART) has reduced the risk of Kaposi sarcoma (KS), KS cases still occur in HIV-infected people. To describe all KS cases observed between 2010 and 2015 in a country with high ART coverage. Retrospective study using longitudinal data from 44 642 patients in the French Dat'AIDS multicenter cohort. Patients' characteristics were described at KS diagnosis according to ART exposure and to HIV-plasma viral load (HIV-pVL) (≤50 or >50) copies/mL. Among the 209 KS cases diagnosed during the study period, 33.2% occurred in ART naïve patients, 17.3% in ART-experienced patients and 49.5% in patients on ART, of whom 23% for more than 6 months. Among these patients, 24 (11.5%) had HIV-pVL ≤50 cp/mL, and 16 (66%) were treated with a boosted-PI-based regimen. The distribution of KS localization did not differ by ART status nor by year of diagnosis. Data on human herpesvirus 8, treatment modalities for KS and response rate were not collected. Half of KS cases observed in the study period occurred in patients not on ART, reflecting the persistence of late HIV diagnosis. Factors associated with KS in patients on ART with HIV-pVL ≤50 cp/mL remain to be explored.

Sections du résumé

BACKGROUND BACKGROUND
Although antiretroviral therapy (ART) has reduced the risk of Kaposi sarcoma (KS), KS cases still occur in HIV-infected people.
OBJECTIVE OBJECTIVE
To describe all KS cases observed between 2010 and 2015 in a country with high ART coverage.
METHODS METHODS
Retrospective study using longitudinal data from 44 642 patients in the French Dat'AIDS multicenter cohort. Patients' characteristics were described at KS diagnosis according to ART exposure and to HIV-plasma viral load (HIV-pVL) (≤50 or >50) copies/mL.
RESULTS RESULTS
Among the 209 KS cases diagnosed during the study period, 33.2% occurred in ART naïve patients, 17.3% in ART-experienced patients and 49.5% in patients on ART, of whom 23% for more than 6 months. Among these patients, 24 (11.5%) had HIV-pVL ≤50 cp/mL, and 16 (66%) were treated with a boosted-PI-based regimen. The distribution of KS localization did not differ by ART status nor by year of diagnosis.
LIMITATIONS CONCLUSIONS
Data on human herpesvirus 8, treatment modalities for KS and response rate were not collected.
CONCLUSION CONCLUSIONS
Half of KS cases observed in the study period occurred in patients not on ART, reflecting the persistence of late HIV diagnosis. Factors associated with KS in patients on ART with HIV-pVL ≤50 cp/mL remain to be explored.

Identifiants

DOI: 10.1111/jdv.16204 PMID: 31953902 PMC: PMC7318618
pubmed: 31953902
doi: 10.1111/jdv.16204
pmc: PMC7318618
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

1065-1073

Investigateurs

C Drobacheff-Thiébaut (C)
A Foltzer (A)
K Bouiller (K)
C Chirouze (C)
Q Lepiller (Q)
F Bozon (F)
O Babre (O)
A S Brunel (AS)
P Muret (P)
H Laurichesse (H)
O Lesens (O)
M Vidal (M)
N Mrozek (N)
C Aumeran (C)
O Baud (O)
V Corbin (V)
P Letertre-Gibert (P)
S Casanova (S)
J Prouteau (J)
I Fabre (I)
E Curlier (E)
R Ouissa (R)
C Herrmann-Storck (C)
B Tressieres (B)
T Bonijoly (T)
M C Receveur (MC)
F Boulard (F)
C Daniel (C)
C Clavel (C)
D Merrien (D)
P Perré (P)
T Guimard (T)
O Bollangier (O)
S Leautez (S)
M Morrier (M)
L Laine (L)
F Ader (F)
A Becker (A)
F Biron (F)
A Boibieux (A)
L Cotte (L)
P Miailhes (P)
T Perpoint (T)
S Roux (S)
C Triffault-Fillit (C)
S Degroodt (S)
C Brochier (C)
F Valour (F)
C Chidiac (C)
A Ménard (A)
A Y Belkhir (AY)
P Colson (P)
C Dhiver (C)
A Madrid (A)
M Martin-Degioanni (M)
L Meddeb (L)
M Mokhtari (M)
A Motte (A)
A Raoux (A)
I Ravaux (I)
C Tamalet (C)
C Toméi (C)
H Tissot Dupont (H)
O Zaegel-Faucher (O)
H Laroche (H)
M Orticoni (M)
M J Soavi (MJ)
P Geneau de Lamarlière (P)
E Ressiot (E)
M J Ducassou (MJ)
I Jaquet (I)
S Galie (S)
A Galinier (A)
P Martinet (P)
M Landon (M)
A S Ritleng (AS)
A Ivanova (A)
C Debreux (C)
S Abel (S)
O Cabras (O)
L Cuzin (L)
K Guitteaud (K)
M Illiaquer (M)
S Pierre-François (S)
L Osei (L)
J Pasquier (J)
K Rome (K)
E Sidani (E)
J M Turmel (JM)
C Varache (C)
N Atoui (N)
M Bistoquet (M)
E Delaporte (E)
V Le Moing (V)
N Meftah (N)
C Merle de Boever (C)
B Montes (B)
A Montoya Ferrer (A)
E Tuaillon (E)
J Reynes (J)
M André (M)
L Boyer (L)
M P Bouillon (MP)
M Delestan (M)
C Rabaud (C)
T May (T)
B Hoen (B)
C Bernaud (C)
E Billaud (E)
C Biron (C)
B Bonnet (B)
S Bouchez (S)
D Boutoille (D)
C Brunet-Cartier (C)
C Deschanvres (C)
N Hall (N)
T Jovelin (T)
P Morineau (P)
V Reliquet (V)
S Sécher (S)
M Cavellec (M)
A Soria (A)
E Paredes (E)
V Ferré (V)
E André-Garnier (E)
A Rodallec (A)
M Lefebvre (M)
O Grossi (O)
O Aubry (O)
F Raffi (F)
S Breaud (S)
C Ceppi (C)
D Chirio (D)
E Cua (E)
P Dellamonica (P)
E Demonchy (E)
A De Monte (A)
J Durant (J)
C Etienne (C)
S Ferrando (S)
R Garraffo (R)
C Michelangeli (C)
V Mondain (V)
A Naqvi (A)
N Oran (N)
I Perbost (I)
S Pillet (S)
C Pradier (C)
B Prouvost-Keller (B)
K Risso (K)
V Rio (V)
P M Roger (PM)
E Rosenthal (E)
S Sausse (S)
I Touitou (I)
S Wehrlen-Pugliese (S)
G Zouzou (G)
L Hocqueloux (L)
T Prazuck (T)
C Gubavu (C)
A Sève (A)
A Maka (A)
C Boulard (C)
G Thomas (G)
C Goujard (C)
Y Quertainmont (Y)
E Teicher (E)
N Lerolle (N)
O Deradji (O)
A Barrail-Tran (A)
R Landman (R)
V Joly (V)
J Ghosn (J)
C Rioux (C)
S Lariven (S)
A Gervais (A)
F X Lescure (FX)
S Matheron (S)
F Louni (F)
Z Julia (Z)
C Mackoumbou-Nkouka (C)
S Le Gac (S)
C Charpentier (C)
D Descamps (D)
G Peytavin (G)
Y Yazdanpanah (Y)
K Amazzough (K)
G Benabdelmoumen (G)
P Bossi (P)
G Cessot (G)
C Charlier (C)
P H Consigny (PH)
F Danion (F)
A Dureault (A)
J Goesch (J)
R Guery (R)
B Henry (B)
K Jidar (K)
F Lanternier (F)
P Loubet (P)
O Lortholary (O)
C Louisin (C)
J Lourenco (J)
P Parize (P)
B Pilmis (B)
F Touam (F)
M A Valantin (MA)
R Tubiana (R)
R Agher (R)
S Seang (S)
L Schneider (L)
C Blanc (C)
C Katlama (C)
J L Berger (JL)
Y N'Guyen (Y)
D Lambert (D)
I Kmiec (I)
M Hentzien (M)
A Brunet (A)
V Brodard (V)
P Tattevin (P)
M Revest (M)
F Souala (F)
M Baldeyrou (M)
S Patrat-Delon (S)
J M Chapplain (JM)
F Benezit (F)
M Dupont (M)
M Poinot (M)
A Maillard (A)
C Pronier (C)
F Lemaitre (F)
C Guennoun (C)
M Poisson-Vanier (M)
T Jovelin (T)
J P Sinteff (JP)
C Arvieux (C)
E Botelho-Nevers (E)
A Gagneux-Brunon (A)
A Frésard (A)
V Ronat (V)
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P Fischer (P)
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C Bernard-Henry (C)
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A Debard (A)
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M Pradier (M)
O Robineau (O)
N Viget (N)
M Valette (M)

Informations de copyright

© 2020 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.

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Auteurs

I Poizot-Martin (I)

Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, APHM Sainte-Marguerite, Service d'Immuno-Hématologie Clinique, Marseille, France.
ORCID: 0000-0002-5676-5411

V Obry-Roguet (V)

Aix-Marseille Université, APHM Sainte-Marguerite, Service d'Immuno-Hématologie Clinique, Marseille, France.

C Duvivier (C)

Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, APHP-Hôpital Necker-Enfants Malades, Paris, France.
IHU Imagine, Paris, France.
Institut Cochin - CNRS 8104 - INSERM U1016 - RIL Team: Retrovirus, Infection and Latency, Université de Paris, Paris, France.
Centre Médical de l'Institut Pasteur, Institut Pasteur, Paris, France.

C Lions (C)

Aix-Marseille Université, APHM Sainte-Marguerite, Service d'Immuno-Hématologie Clinique, Marseille, France.

T Huleux (T)

Service Universitaire des Maladies Infectieuses et du Voyageur - Centre Hospitalier G. DRON, Tourcoing, France.

C Jacomet (C)

Centre Hospitalier Universitaire de Clermont-Ferrand, Département des Maladies Infectieuses et Tropicales, Clermont Ferrand, France.

T Ferry (T)

Service de Maladies Infectieuses, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France.

A Cheret (A)

Sorbonne Paris Cité, EA7327, Université Paris Descartes, Paris, France.
Service de Médecine Interne - Immunologie Clinique - Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.

C Allavena (C)

Service des Maladies Infectieuses et Tropicales, CHU Hôtel-Dieu, Nantes, France.

F Bani-Sadr (F)

Département de Médecine Interne, Maladies Infectieuses et Immunologie Clinique, Hêpital Robert Debré, Centre Hospitalier Universitaire, Reims, France.

R Palich (R)

Service des Maladies Infectieuses et Tropicales, GHPS Pitié Salpêtrière APHP, Paris, France.
UMR 1136, Sorbonne Universités UPMC Université Paris 6-INSERM-IPLESP, Paris, France.

A Cabié (A)

Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Martinique, Fort-de-France, France.
EA 4537 Maladies Infectieuses et Tropicales dans la Caraï be, Université des Antilles, Pointe-à-Pitre, France.
INSERM CIC1424 Centre d'Investigation Clinique Antilles Guyane, Centre Hospitalier Andrée Rosemon, Cayenne, France.

A Fresard (A)

Centre Hospitalier Universitaire de Saint-Étienne, Département des Maladies Infectieuses et Tropicales, Saint-Etienne, France.

P Pugliese (P)

CHU de Nice, Universite Côte d'Azur, Nice, France.

P Delobel (P)

CHU de Toulouse, Service des Maladies Infectieuses et Tropicales-INSERM, UMR1043-Université Toulouse III Paul Sabatier, Toulouse, France.

I Lamaury (I)

Département d'Infectiologie, Dermatologie et Immunologie Clinique, Pointe-à-Pitre Cedex, France.

L Hustache-Mathieu (L)

Service des Maladies Infectieuses et Tropicales, CHRU de Besançon - Hôpital Jean Minjoz, Besançon, France.

S Brégigeon (S)

Aix-Marseille Université, APHM Sainte-Marguerite, Service d'Immuno-Hématologie Clinique, Marseille, France.

A Makinson (A)

Centre Hospitalier Universitaire de Montpellier, Département des Maladies Infectieuses et Tropicales, INSERM U1175/IRD UMI 233, Montpellier, France.

D Rey (D)

Le Trait d'Union, Centre de Soins de l'infection par le VIH, Hôpitaux Universitaires, Strasbourg, France.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Syndrome d'immunodéficience acquise › Kaposi sarcoma among people living with HIV in...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Kaposi sarcoma among people living with HIV in...
questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Gammaherpesvirinae › Rhadinovirus › Herpèsvirus humain de type 8 › Kaposi sarcoma among people living with HIV in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Kaposi sarcoma among people living with HIV in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Kaposi sarcoma among people living with HIV in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu vasculaire › Sarcome de Kaposi › Kaposi sarcoma among people living with HIV in...