Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short-Chain Fatty Acids.
Acetates
/ administration & dosage
Administration, Oral
Animals
Antihypertensive Agents
/ administration & dosage
Bifidobacterium breve
Blood Pressure
/ drug effects
Cardiomegaly
/ prevention & control
Dietary Supplements
Dysbiosis
/ microbiology
Fatty Acids, Volatile
/ analysis
Gastrointestinal Microbiome
Hypertension
/ diet therapy
Male
Probiotics
/ administration & dosage
Rats, Inbred SHR
Rats, Inbred WKY
T-Lymphocytes
endothelial dysfunction
gut microbiota
hypertension
immune system
probiotic bacteria
spontaneously hypertensive rats
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
06
06
2019
revised:
30
12
2019
pubmed:
19
1
2020
medline:
5
6
2021
entrez:
19
1
2020
Statut:
ppublish
Résumé
The objective of this study is to determine the cardiovascular effects of the probiotics Bifidobacterium breve CECT7263 (BFM) and Lactobacillus fermentum CECT5716 (LC40), and the short chain fatty acids butyrate, and acetate in spontaneously hypertensive rats (SHR). Ten five-week old Wistar Kyoto rats (WKY) and fifty aged-matched SHR are randomly distributed into six groups: control WKY, control SHR, treated SHR-LC40, treated SHR-BMF, treated SHR-butyrate, and treated SHR-acetate. Chronic treatments with LC40 or BFM increase butyrate-producing bacteria and prevent the blood pressure increase in SHR. Oral treatment with butyrate or acetate also prevents the increase in both blood pressure and Firmicutes/Bacteroidetes (F/B) ratio. All treatments restore the Th17/Treg balance in mesenteric lymph nodes, normalized endotoxemia, and prevent the impairment of endothelium-dependent relaxation to acetylcholine, as a result of reduced NADPH oxidase-driven reactive oxygen species production. These protective effects might be mediated by both the reduction in vascular lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4) pathway and the increase in Treg infiltration in the vasculature. The probiotics LC40 and BFM prevent dysbiosis and the development of endothelial dysfunction and high blood pressure in genetic hypertension. These effects seem to be related to endotoxemia reduction and to increase Treg accumulation in the vasculature.
Identifiants
pubmed: 31953983
doi: 10.1002/mnfr.201900616
doi:
Substances chimiques
Acetates
0
Antihypertensive Agents
0
Fatty Acids, Volatile
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900616Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
T. Yang, M. M. Santisteban, V. Rodriguez, E. Li, N. Ahmari, J. M. Carvajal, M. Zadeh, M. Gong, Y. Qi, J. Zubcevic, B. Sahay, C. J. Pepine, M. K. Raizada, M. Mohamadzadeh, Hypertension 2015, 65, 1331.
B. Mell, V. R. Jala, A. V. Mathew, J. Byun, H. Waghulde, Y. Zhang, B. Haribabu, M. Vijay-Kumar, S. Pennathur, B. Joe, Physiol. Genomics. 2015, 47, 187.
L. F. Gomez-Arango, H. L. Barrett, H. D. McIntyre, L. K. Callaway, M. Morrison, M. Dekker Nitert, S. T. Group, Hypertension 2016, 68, 974.
J. Li, F. Zhao, Y. Wang, J. Chen, J. Tao, G. Tian, S. Wu, W. Liu, Q. Cui, B. Geng, W. Zhang, R. Weldon, K. Auguste, L. Yang, X. Liu, L. Chen, X. Yang, B. Zhu, J. Cai, Microbiome 2017, 5, 14.
F. Z. Marques, E. Nelson, P. Y. Chu, D. Horlock, A. Fiedler, M. Ziemann, J. K. Tan, S. Kuruppu, N. W. Rajapakse, A. El-Osta, C. R. Mackay, D. M. Kaye, Circulation. 2017, 135, 964.
S. Sun, A. Lulla, M. Sioda, K. Winglee, M. C. Wu, D. R. Jacobs, Jr., J. M. Shikany, D. M. Lloyd-Jones, L. J. Launer, A. A. Fodor, K. A. Meyer, Hypertension. 2019, 73, 998.
S. H. Karbach, T. Schonfelder, I. Brandao, E. Wilms, N. Hormann, S. Jackel, R. Schuler, S. Finger, M. Knorr, J. Lagrange, M. Brandt, A. Waisman, S. Kossmann, K. Schafer, T. Munzel, C. Reinhardt, P. Wenzel, J Am Heart Assoc. 2016, 5, e003698.
S. Adnan, J. W. Nelson, N. J. Ajami, V. R. Venna, J. F. Petrosino, R. M. Bryan, Jr., D. J. Durgan, Physiol. Genomics. 2017, 49, 96.
M. Toral, I. Robles-Vera, N. de la Visitacion, M. Romero, T. Yang, M. Sanchez, M. Gomez-Guzman, R. Jimenez, M. K. Raizada, J. Duarte, Front Physiol. 2019, 10, 231.
M. Toral, I. Robles-Vera, N. de la Visitacion, M. Romero, M. Sanchez, M. Gomez-Guzman, A. Rodriguez-Nogales, T. Yang, R. Jimenez, F. Algieri, J. Galvez, M. K. Raizada, J. Duarte, Acta Physiol. 2019, 227, e13285.
F. Z. Marques, C. R. Mackay, D. M. Kaye, Nat. Rev. Cardiol. 2018, 15, 20.
J. L. Pluznick, R. J. Protzko, H. Gevorgyan, Z. Peterlin, A. Sipos, J. Han, I. Brunet, L. X. Wan, F. Rey, T. Wang, S. J. Firestein, M. Yanagisawa, J. I. Gordon, A. Eichmann, J. Peti-Peterdi, M. J. Caplan, Proc. Natl. Acad. Sci. USA 2013, 110, 4410.
M. Caroff, D Karibian, Carbohydr. Res. 2003, 338, 2431.
S. Kim, G. Wang, G. Lobaton, E. Li, T. Yang, M. Raizada. J. Hypertens. 2016, 34, e60.
S. Kim, R. Goel, A. Kumar, Y. Qi, G. Lobaton, K. Hosaka, M. Mohammed, E. M. Handberg, E. M. Richards, C. J. Pepine, M. K. Raizada, Clin. Sci. 2018, 132, 701.
A. Bartley, T. Yang, R. Arocha, W. L. Malphurs, R. Larkin, K. L. Magee, T. W. Vickroy, J. Zubcevic, Front. Physiol. 2018, 9, 1593.
G. F. Bomfim, R. A. Dos Santos, M. A. Oliveira, F. R. Giachini, E. H. Akamine, R. C. Tostes, Z. B. Fortes, R. C. Webb, M. H. Carvalho, Clin. Sci. 2012, 122, 535.
S. Khalesi, J. Sun, N. Buys, R. Jayasinghe, Hypertension. 2014, 64, 897.
M. Gomez-Guzman, M. Toral, M. Romero, R. Jimenez, P. Galindo, M. Sanchez, M. J. Zarzuelo, M. Olivares, J. Galvez, J. Duarte, Mol. Nutr. Food Res. 2015, 59, 2326.
A. G. Friques, C. M. Arpini, I. C. Kalil, A. L. Gava, M. A. Leal, M. L. Porto, B. V. Nogueira, A. T. Dias, T. U. Andrade, T. M. Pereira, S. S. Meyrelles, B. P. Campagnaro, E. C. Vasquez, J. Translat. Med. 2015, 13, 390.
W. B. Yap, F. M. Ahmad, Y. C. Lim, S. Zainalabidin, Korean J. Physiol. Pharmacol. 2016, 20, 621.
E. Galkina, A. Kadl, J. Sanders, D. Varughese, I. J. Sarembock, K. Ley, J. Exp. Med. 2006, 203, 1273.
N. A. Bokulich, S. Subramanian, J. J. Faith, D. Gevers, J. I. Gordon, R. Knight, D. A. Mills, J. G. Caporaso, Nat. Methods. 2013, 10, 57.
N. Segata, J. Izard, L. Waldron, D. Gevers, L. Miropolsky, W. S. Garrett, C. Huttenhower, Genome Biol. 2011, 12, R60.
T. Yang, E. M. Richards, C. J. Pepine, M. K. Raizada, Nat. Rev. Nephrol. 2018, 14, 442.
L. Krych, D. S. Nielsen, A. K. Hansen, C. H. Hansen, Gut Microbes. 2015, 6, 101.
Y. Furusawa, Y. Obata, S. Fukuda, T. A. Endo, G. Nakato, D. Takahashi, Y. Nakanishi, C. Uetake, K. Kato, T. Kato, M. Takahashi, N. N. Fukuda, S. Murakami, E. Miyauchi, S. Hino, K. Atarashi, S. Onawa, Y. Fujimura, T. Lockett, J. M. Clarke, D. L. Topping, M. Tomita, S. Hori, O. Ohara, T. Morita, H. Koseki, J. Kikuchi, K. Honda, K. Hase, H. Ohno, Nature. 2013, 504, 446.
N. Arpaia, C. Campbell, X. Fan, S. Dikiy, J. van der Veeken, P. deRoos, H. Liu, J. R. Cross, K. Pfeffer, P. J. Coffer, A. Y. Rudensky, Nature. 2013, 504, 451.
P. M. Smith, M. R. Howitt, N. Panikov, M. Michaud, C. A. Gallini, Y. M. Bohlooly, J. N. Glickman, W. S. Garrett, Science 2013, 341, 569.
S. Sugiyama, T. Fushimi, M. Kishi, S. Irie, S. Tsuji, N. Hosokawa, T. Kaga, J. Nutr. Sci. Vitaminol. 2010, 56, 266.
A. P. Halestrap, Compr Physiol. 2013, 3, 1611.
X. Chen, W. Su, T. Wan, J. Yu, W. Zhu, F. Tang, G. Liu, N. Olsen, D. Liang, S. G. Zheng, Biochem. Pharmacol. 2017, 142, 111.
M. Zhang, Y. Zhang, Z. Li, C. Zhang, X. Tan, X. Liu, C. Wan, X. Yang, D. J. Lee, J. Environ. Eng. Manage. 2019, 232, 197.
E.C. Aguilar, L.C. Santos, A.J. Leonel, J.S. de Oliveira, E.A. Santos, J.M. Navia-Pelaez, J.F. da Silva, B.P. Mendes, L.S. Capettini, L.G. Teixeira, V.S. Lemos, J.I. Alvarez-Leite. J. Nutr. Biochem. 2016, 34, 99.
M. M. Santisteban, Y. Qi, J. Zubcevic, S. Kim, T. Yang, V. Shenoy, C. T. Cole-Jeffrey, G. O. Lobaton, D. C. Stewart, A. Rubiano, C. S. Simmons, F. Garcia-Pereira, R. D. Johnson, C. J. Pepine, M. K. Raizada, Circ. Res. 2017, 120, 312.
N. Huang, J. P. Katz, D. R. Martin, G. D. Wu, Cytokine 1997, 9, 27.
H. M. Hamer, D. M. Jonkers, A. Bast, S. A. Vanhoutvin, M. A. Fischer, A. Kodde, F. J. Troost, K. Venema, R. J. Brummer, Clin. Nutr. 2009, 28, 88.
E. Elinav, J. Henao-Mejia, R. A. Flavell, Mucosal Immunol. 2013, 6, 4.
L. Peng, Z. He, W. Chen, I. R. Holzman, J. Lin, Avian Pathol. 2007, 61, 37.
K. Van Deun, F. Haesebrouck, F. Van Immerseel, R. Ducatelle, F. Pasmans, Avian Pathol. 2008, 37, 379.
E. E. Elamin, A. A. Masclee, J. Dekker, H. J. Pieters, D. M. Jonkers, J. Nutr. 2013, 143, 1872.
T. Suzuki, S. Yoshida, H. Hara, Br. J. Nutr. 2008, 100, 297.
J. M. Mariadason, Epigenetics 2008, 3, 28.
A. M. Mowat, W. W. Agace, Nat. Rev. Immunol. 2014, 14, 667.
J. H. Niess, S. Brand, X. Gu, L. Landsman, S. Jung, B. A. McCormick, J. M. Vyas, M. Boes, H. L. Ploegh, J. G. Fox, D. R. Littman, H. C. Reinecker, Science. 2005, 307, 254.
O. J. Harrison, N. Srinivasan, J. Pott, C. Schiering, T. Krausgruber, N. E. Ilott, K. J. Maloy, Mucosal Immunol. 2015, 8, 1226.
D. Sollinger, R. Eißler, S. Lorenz, S. Strand, S. Chmielewski, C. Aoqui, C. Schmaderer, H. Bluyssen, J. Zicha, O. Witzke, F. Scherer, J. Lutz, U. Heemann, M. Baumann, Cardiovasc. Res. 2014, 101, 464.
C. F. Liang, J. T. Liu, Y. Wang, A. Xu, P. M. Vanhoutte, Arterioscler., Thromb., Vasc. Biol. 2013, 33, 777.
M. Toral, M. Gomez-Guzman, R. Jimenez, M. Romero, M. Sanchez, M. P. Utrilla, N. Garrido-Mesa, M. E. Rodriguez-Cabezas, M. Olivares, J. Galvez, J. Duarte, Clin. Sci. 2014, 127, 33.
M. J. Ryan, Hypertension. 2013, 62, 226.
H. Nguyen, V. L. Chiasson, P. Chatterjee, S. E. Kopriva, K. J. Young, B. M. Mitchell, Cardiovasc. Res. 2013, 97, 696.
M. Katsuki, Y. Hirooka, T. Kishi, K. Sunagawa, J. Hypertens. 2015, 33, 773.
M. Kassan, M. Galan, M. Partyka, M. Trebak, K. Matrougui, Arterioscler., Thromb., Vasc. Biol. 2011, 31, 2534.
L.V. d'Uscio, L.A. Smith, Z.S. Katusic, Am. J. Physiol.: Heart Circ. Physiol. 2011, 301, H2227.
J. L. Izquierdo-Garcia, I. Rodriguez, A. Kyriazis, P. Villa, P. Barreiro, M. Desco, J. Ruiz-Cabello, BMC Bioinformatics. 2009, 10, 363.
O. Juanola, J. Ferrusquía-Acosta, R. García-Villalba, P. Zapater, M. Magaz, A. Marín, P. Olivas, A. Baiges, P. Bellot, F. Turon, V. Hernández-Gea, J.M. González-Navajas, F.A. Tomás-Barberán, J.C. García-Pagán, R. Francés, FASEB J. 2019, 33, 11595.
F. Algieri, A. Rodríguez-Nogales, N. Garrido-Mesa, T. Vezza, J. Garrido-Mesa, M.P. Utrilla, A. Montilla, A. Cardelle-Cobas, A. Olano, N. Corzo, E. Guerra-Hernández, A. Zarzuelo, M.E. Rodriguez-Cabezas, J. Galvez, J. Agric. Food Chem. 2014, 62, 4285.