Cellular Dialogues: Cell-Cell Communication through Diffusible Molecules Yields Dynamic Spatial Patterns.
cell-cell communication
cellular automata
complex systems
gene networks
multicellular systems
pattern formation
reaction-diffusion
self organization
spatial patterns
waves
Journal
Cell systems
ISSN: 2405-4720
Titre abrégé: Cell Syst
Pays: United States
ID NLM: 101656080
Informations de publication
Date de publication:
22 01 2020
22 01 2020
Historique:
received:
30
07
2019
revised:
16
10
2019
accepted:
04
12
2019
pubmed:
20
1
2020
medline:
9
6
2021
entrez:
20
1
2020
Statut:
ppublish
Résumé
Cells form spatial patterns by coordinating their gene expressions. How a group of mesoscopic numbers (hundreds to thousands) of cells, without pre-existing morphogen gradients and spatial organization, self-organizes spatial patterns remains poorly understood. Of particular importance are dynamic spatial patterns such as spiral waves that perpetually move and transmit information. We developed an open-source software for simulating a field of cells that communicate by secreting any number of molecules. With this software and a theory, we identified all possible "cellular dialogues"-ways of communicating with two diffusing molecules-that yield diverse dynamic spatial patterns. These patterns emerge despite widely varying responses of cells to the molecules, gene-expression noise, spatial arrangements, and cell movements. A three-stage, "order-fluctuate-settle" process forms dynamic spatial patterns: cells form long-lived whirlpools of wavelets that, following erratic dynamics, settle into a dynamic spatial pattern. Our work helps in identifying gene-regulatory networks that underlie dynamic pattern formations.
Identifiants
pubmed: 31954659
pii: S2405-4712(19)30431-4
doi: 10.1016/j.cels.2019.12.001
pmc: PMC6975168
pii:
doi:
Banques de données
Dryad
['10.5061/dryad.6hdr7sqw5']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-98.e7Subventions
Organisme : European Research Council
ID : 677972
Pays : International
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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