Relation of Plasma Xanthine Oxidoreductase Activity to Coronary Lipid Core Plaques Assessed by Near-Infrared Spectroscopy Intravascular Ultrasound in Patients With Stable Coronary Artery Disease.
Aged
Biomarkers
/ blood
Coronary Angiography
Coronary Artery Disease
/ blood
Coronary Vessels
/ diagnostic imaging
Female
Follow-Up Studies
Humans
Lipids
/ blood
Male
Plaque, Atherosclerotic
/ blood
Retrospective Studies
Spectroscopy, Near-Infrared
/ methods
Ultrasonography, Interventional
/ methods
Xanthine Dehydrogenase
/ blood
Journal
The American journal of cardiology
ISSN: 1879-1913
Titre abrégé: Am J Cardiol
Pays: United States
ID NLM: 0207277
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
01
11
2019
revised:
19
12
2019
accepted:
23
12
2019
pubmed:
21
1
2020
medline:
26
6
2020
entrez:
21
1
2020
Statut:
ppublish
Résumé
Previous studies reported that elevated serum uric acid level was associated with greater coronary lipid plaque. Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine metabolism and is believed to play important roles in coronary atherosclerosis. However, the relation between XOR and coronary lipid plaque is unclear. Patients with stable coronary artery disease who underwent elective percutaneous coronary intervention under near-infrared spectroscopy intravascular ultrasound (NIRS-IVUS) guidance were prospectively included. They were divided into 3 groups according to plasma XOR activities based on a previous report: low, normal, and high. Quantitative coronary angiography and gray-scale IVUS were analyzed. The primary end point was coronary lipid plaques in a nontarget vessel assessed by NIRS-IVUS with lipid core burden index (LCBI) and maximum LCBI in 4 mm (maxLCBI
Identifiants
pubmed: 31955828
pii: S0002-9149(20)30010-2
doi: 10.1016/j.amjcard.2019.12.043
pii:
doi:
Substances chimiques
Biomarkers
0
Lipids
0
Xanthine Dehydrogenase
EC 1.17.1.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1006-1012Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.