Limited Associations Between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients With Depression.

5-HT receptor genes antidepressant polymorphism treatment response treatment-free depression

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2019
Historique:
received: 10 09 2019
accepted: 13 11 2019
entrez: 21 1 2020
pubmed: 21 1 2020
medline: 21 1 2020
Statut: epublish

Résumé

Major depressive disorder has become a prominent cause of disability, as lifetime prevalence has increased to ~15% in the Western world. Pharmacological effects of serotonin (5-hydroxytryptamine, 5-HT) are mediated through 5-hydroxytryptamine receptor (5-HTR) binding. Serotonin regulation of amygdala activity is attained through activation of three 5-HT2 family receptor subtypes, 5-HT2A, 5-HT2B, and 5-HT2C. Specifically, HT2A and the HT2C receptors have similar gross cerebral distribution and function, with higher constitutive activity found in HT2C than in HT2A. We investigated the possible association of 5-HTR gene polymorphisms to specific and non-specific antidepressant treatment responses in treatment-free patients in Siberia. 156 patients, aged between 18-70 years and clinically diagnosed with depressive disorders, were treated with antidepressants for 4 weeks. Patients were genotyped for a subset of 29 SNPs from the following 5-HT Receptor genes: HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6. Primary outcome was measured by differences in Hamilton Depression Rating Scale (ΔHAM-D 17) scores between baseline/week two, week two/week four and baseline/week four. Univariate linear regression was initially conducted to determine the 5-HTR SNPs to be studied within the multiple linear regression. Multiple linear regression analyses over the three time periods were conducted for ΔHAM-D 17 with independent factors including: age, gender, depression diagnosis, antidepressant treatment and selected 5-HTR SNPs. We found improved ∆HAM-D 17 in patients taking tricyclic antidepressants (0-4 weeks: B = 4.85, p = 0.0002; 0-2 weeks: B = 3.58, p = 0.002) compared to patients taking SSRIs. Over the course of study, significant associations between 5-HT receptors SNPs and antidepressant response were not identified.

Identifiants

pubmed: 31956308
doi: 10.3389/fphar.2019.01462
pmc: PMC6951408
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1462

Informations de copyright

Copyright © 2019 Ochi, Vyalova, Losenkov, Paderina, Pozhidaev, Loonen, Simutkin, Bokhan, Ivanova and Wilffert.

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Auteurs

Taichi Ochi (T)

Department of PharmacoTherapy, - Epidemiology & -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.

Natalya M Vyalova (NM)

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Innokentiy S Losenkov (IS)

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Diana Z Paderina (DZ)

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Department of Cytology and Genetics, National Research Tomsk State University, Tomsk, Russia.

Ivan V Pozhidaev (IV)

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Department of Cytology and Genetics, National Research Tomsk State University, Tomsk, Russia.

Anton J M Loonen (AJM)

Department of PharmacoTherapy, - Epidemiology & -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
GGZ Westelijk Noord-Brabant, Policy Office for Quality and Innovation of Care (BZI), Halsteren, Netherlands.

German G Simutkin (GG)

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Nikolay A Bokhan (NA)

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Department of Psychotherapy and Psychological Counseling, National Research Tomsk State University, Tomsk, Russia.
Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, Tomsk, Russia.

Svetlana A Ivanova (SA)

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, Tomsk, Russia.
School of Non-Destructive Testing and Security, Division for Control and Diagnostics, National Research Tomsk Polytechnic University, Tomsk, Russia.

Bob Wilffert (B)

Department of PharmacoTherapy, - Epidemiology & -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Classifications MeSH