Proteome-wide analysis of T-cell response to BK polyomavirus in healthy virus carriers and kidney transplant recipients reveals a unique transcriptional and functional profile.
T cells
adaptive immunity
cellular immunity
immunology
immunotherapy
infectious diseases
innate immune cells
lymphocytes
viral infection
Journal
Clinical & translational immunology
ISSN: 2050-0068
Titre abrégé: Clin Transl Immunology
Pays: Australia
ID NLM: 101638268
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
07
2019
revised:
15
12
2019
accepted:
19
12
2019
entrez:
21
1
2020
pubmed:
21
1
2020
medline:
21
1
2020
Statut:
epublish
Résumé
Cellular immunity against BK polyomavirus (BKV)-encoded antigens plays a crucial role in long-term protection against virus-associated pathogenesis in transplant recipients. However, in-depth understanding on dynamics of these cellular immune responses is required to develop better immune monitoring and immunotherapeutic strategies. Here, we have conducted a proteome-wide analysis of BKV-specific T-cell responses in a cohort of 53 healthy individuals and 26 kidney transplant recipients to delineate the functional and transcriptional profile of these effector cells and compared these characteristics to T cells directed against cytomegalovirus, which is also known to cause significant morbidity in transplant recipients. Profiling of BKV-specific CD4 These observations provide an important platform for the future development of immune monitoring and adoptive T-cell therapy strategies for BKV-associated diseases in transplant recipients, which may also be exploited for similar therapeutic value in JCV-associated clinical complications.
Identifiants
pubmed: 31956413
doi: 10.1002/cti2.1102
pii: CTI21102
pmc: PMC6960379
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e01102Informations de copyright
© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology Inc.
Déclaration de conflit d'intérêts
GA, BTA and RK are listed as inventors on international patent application that includes multiple BKV epitopes. RK and CS are consultants for Atara Biotherapeutics and received research support from Atara Biotherapeutics.
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