Large granular lymphocytic leukaemia after solid organ and haematopoietic stem cell transplantation.
bone marrow transplantation
large granular lymphocytic leukaemia
solid organ transplantation
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
07
07
2019
revised:
04
09
2019
accepted:
09
09
2019
pubmed:
21
1
2020
medline:
15
12
2020
entrez:
21
1
2020
Statut:
ppublish
Résumé
T-cell large granular lymphocytic leukaemia (T-LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T-LGLL seen at our institution over the last 10 years, we encountered 15 cases following solid organ or haematopoietic stem cell transplantation. Here, we studied the clinical characterization of these cases and compared them to de novo T-LGLL. This experience represented a clear picture of the intricate nature of the disease manifestation and the complexities of several immune mechanisms triggering the clonal expansion.
Identifiants
pubmed: 31958160
doi: 10.1111/bjh.16336
pmc: PMC8370478
mid: NIHMS1054457
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
318-322Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL118281
Pays : United States
Organisme : NIH HHS
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135795
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123904
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132071
Pays : United States
Informations de copyright
© 2019 British Society for Haematology and John Wiley & Sons Ltd.
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