Urea removal strategies for dialysate regeneration in a wearable artificial kidney.

Dialysis Solutions Humans Kidneys, Artificial Regeneration Renal Dialysis Urea Wearable Electronic Devices
Artificial kidney Electro oxidation Hemodialysis Sorbent Urea Urease

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
03 2020
Historique:
received: 25 07 2019
revised: 05 12 2019
accepted: 25 12 2019
pubmed: 21 1 2020
medline: 15 5 2021
entrez: 21 1 2020
Statut: ppublish

Résumé

The availability of a wearable artificial kidney (WAK) that provides dialysis outside the hospital would be an important advancement for dialysis patients. The concept of a WAK is based on regeneration of a small volume of dialysate in a closed-loop. Removal of urea, the primary waste product of nitrogen metabolism, is the major challenge for the realization of a WAK since it is a molecule with low reactivity that is difficult to adsorb while it is the waste solute with the highest daily molar production. Currently, no efficient urea removal technology is available that allows for miniaturization of the WAK to a size and weight that is acceptable for patients to carry. Several urea removal strategies have been explored, including enzymatic hydrolysis by urease, electro-oxidation and sorbent systems. However, thus far, these methods have toxic side effects, limited removal capacity or slow removal kinetics. This review discusses different urea removal strategies for application in a wearable dialysis device, from both a chemical and a medical perspective.

Identifiants

DOI: 10.1016/j.biomaterials.2019.119735 PMID: 31958714
pubmed: 31958714
pii: S0142-9612(19)30853-1
doi: 10.1016/j.biomaterials.2019.119735
pii:
doi:

Substances chimiques

Dialysis Solutions 0
Urea 8W8T17847W

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

119735

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Maaike K van Gelder (MK)

Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.

Jacobus A W Jong (JAW)

Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, the Netherlands.

Laura Folkertsma (L)

Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands; BIOS-Lab on a Chip Group, MESA+ Institute of Nanotechnology, Technical Medical Center, Max Planck Center for Complex Fluid Dynamics, University of Twente, 7522 NH, Enschede, the Netherlands.

Yong Guo (Y)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, the Netherlands.

Christian Blüchel (C)

Dialyss Pte Ltd, 21 Tampines Avenue 1, 529757, Singapore.

Marianne C Verhaar (MC)

Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.

Mathieu Odijk (M)

BIOS-Lab on a Chip Group, MESA+ Institute of Nanotechnology, Technical Medical Center, Max Planck Center for Complex Fluid Dynamics, University of Twente, 7522 NH, Enschede, the Netherlands.

Cornelus F Van Nostrum (CF)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, the Netherlands.

Wim E Hennink (WE)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, the Netherlands.

Karin G F Gerritsen (KGF)

Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands. Electronic address: k.g.f.gerritsen@umcutrecht.nl.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solutions pharmaceutiques › Solutions de dialyse › Urea removal strategies for dialysate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Urea removal strategies for dialysate...
questionsmedicales.fr › Équipement et fournitures › Équipement chirurgical › Organes artificiels › Reins artificiels › Urea removal strategies for dialysate...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Urea removal strategies for dialysate...
questionsmedicales.fr › Thérapeutique › Détoxication par sorption › Dialyse rénale › Urea removal strategies for dialysate...
questionsmedicales.fr › Composés chimiques organiques › Amides › Urée › Urea removal strategies for dialysate...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures électriques › Dispositifs électroniques portables › Urea removal strategies for dialysate...