Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients.
Adolescent
Adult
Aged
Child
Chromosome Mapping
/ methods
Chromosomes, Human, Pair 6
/ genetics
Cohort Studies
Comparative Genomic Hybridization
/ methods
Databases, Genetic
/ statistics & numerical data
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Loss of Heterozygosity
Middle Aged
Neuroblastoma
/ genetics
Survival Rate
Young Adult
Neuroblastoma
distal 6q27 loss
haploinsufficiency
smallest region of overlap
tumor suppressor genes
Journal
Cancer biology & therapy
ISSN: 1555-8576
Titre abrégé: Cancer Biol Ther
Pays: United States
ID NLM: 101137842
Informations de publication
Date de publication:
03 05 2020
03 05 2020
Historique:
pubmed:
22
1
2020
medline:
17
12
2020
entrez:
22
1
2020
Statut:
ppublish
Résumé
Patients with high-risk neuroblastoma (HR-NB) often initially respond to therapy, but afterward they become resistant and disease recurred. Unfortunately, it does not exist one or more specific chromosome defects associated with relapse or refractory NB. Recently, genomic evidence from primary tumors indicated that the distal region of chromosome 6q is loss in HR-NB patients with fatal outcome. We identified a minimal common region of loss of chromosome 6q27 spanning an area of 2.09 Mb by high-resolution DNA copy number data of a small cohort of HR-NB samples carrying 6q loss. This region of loss harbored five genes
Identifiants
pubmed: 31959052
doi: 10.1080/15384047.2019.1704122
pmc: PMC7515498
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
391-399Références
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