Mechanisms of lung toxicity induced by biomass burning aerosols.
Aerosols
Air Pollutants
/ toxicity
Animals
Apoptosis
/ drug effects
Biomass
Bronchoalveolar Lavage Fluid
/ chemistry
Carbon
/ toxicity
Cells, Cultured
Epithelial Cells
/ drug effects
Female
Humans
Inhalation Exposure
/ adverse effects
Lung
/ drug effects
Mice
Mice, Inbred C57BL
Oxidative Stress
/ drug effects
Particulate Matter
/ toxicity
Reactive Oxygen Species
/ analysis
Wood
/ chemistry
Apoptosis
Biomass burning
Health effects
Inflammation
Mitochondria
Nrf2
Oxidative stress
Wood tar particles
Journal
Particle and fibre toxicology
ISSN: 1743-8977
Titre abrégé: Part Fibre Toxicol
Pays: England
ID NLM: 101236354
Informations de publication
Date de publication:
20 01 2020
20 01 2020
Historique:
received:
29
07
2019
accepted:
06
01
2020
entrez:
22
1
2020
pubmed:
22
1
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related impacts and toxicity are still not well known. This study investigated the toxicity of the water-soluble fraction of pyrolyzed wood tar aerosols in exposed mice and lung epithelial cells. Mice exposed to water-soluble wood tar aerosols showed increased inflammatory and oxidative stress responses. Bronchial epithelial cells exposed to the same water-soluble wood tar aerosols showed increased cell death with apoptotic characteristics. Alterations in oxidative status, including changes in reactive oxygen species (ROS) levels and reductions in the expression of antioxidant genes related to the transcription factor Nrf2, were observed and were confirmed by increased levels of MDA, a lipid peroxidation adduct. Damage to mitochondria was observed as an early event responsible for the aforementioned changes. The toxicity and health effect-related mechanisms of water-soluble wood tar were investigated for the first time in the context of biomass burning. Wood tar particles may account for major responses such as cell death, oxidative stress, supression of protection mechnaisms and mitochondrial damaged cause by expsoure to biomass burning aerosols.
Sections du résumé
BACKGROUND
Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related impacts and toxicity are still not well known. This study investigated the toxicity of the water-soluble fraction of pyrolyzed wood tar aerosols in exposed mice and lung epithelial cells.
RESULTS
Mice exposed to water-soluble wood tar aerosols showed increased inflammatory and oxidative stress responses. Bronchial epithelial cells exposed to the same water-soluble wood tar aerosols showed increased cell death with apoptotic characteristics. Alterations in oxidative status, including changes in reactive oxygen species (ROS) levels and reductions in the expression of antioxidant genes related to the transcription factor Nrf2, were observed and were confirmed by increased levels of MDA, a lipid peroxidation adduct. Damage to mitochondria was observed as an early event responsible for the aforementioned changes.
CONCLUSIONS
The toxicity and health effect-related mechanisms of water-soluble wood tar were investigated for the first time in the context of biomass burning. Wood tar particles may account for major responses such as cell death, oxidative stress, supression of protection mechnaisms and mitochondrial damaged cause by expsoure to biomass burning aerosols.
Identifiants
pubmed: 31959190
doi: 10.1186/s12989-020-0337-x
pii: 10.1186/s12989-020-0337-x
pmc: PMC6971884
doi:
Substances chimiques
Aerosols
0
Air Pollutants
0
Particulate Matter
0
Reactive Oxygen Species
0
Carbon
7440-44-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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