Women who received varicella vaccine versus natural infection have different long-term T cell immunity but similar antibody levels.
Cellular immunity
Chickenpox
Fetal anomalies
Flow cytometry
Humoral immunity
Pregnancy
Vaccine
Varicella-zoster virus
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
11 02 2020
11 02 2020
Historique:
received:
02
07
2019
revised:
24
12
2019
accepted:
31
12
2019
pubmed:
22
1
2020
medline:
9
3
2021
entrez:
22
1
2020
Statut:
ppublish
Résumé
Varicella-zoster virus (VZV) infection during pregnancy is associated with serious fetal anomalies. The live-attenuated VZV vaccine was approved in 1995, so many vaccinated women are now of childbearing age. The question of long-term immunity to varicella is critical because breakthrough chickenpox can occur after vaccination. To compare humoral and T cell immunity between women of childbearing age who were immunized by vaccination or chickenpox disease. Non-pregnant females between 18 and 36 years old with a history of VZV immunization (n = 20) or prior chickenpox disease (n = 20) were recruited. IgG antibody titers and T cell responses were measured by flow cytometry-based methods in serum and peripheral blood, respectively. There were no significant differences in median antibody titers between vaccinated and chickenpox groups (p = 0.34). The chickenpox group had significantly higher levels of VZV antigen-specific CD4 T cells (p = 0.004). Natural infection induced higher VZV-specific T cell immune responses than vaccination.
Sections du résumé
BACKGROUND
Varicella-zoster virus (VZV) infection during pregnancy is associated with serious fetal anomalies. The live-attenuated VZV vaccine was approved in 1995, so many vaccinated women are now of childbearing age. The question of long-term immunity to varicella is critical because breakthrough chickenpox can occur after vaccination.
OBJECTIVE
To compare humoral and T cell immunity between women of childbearing age who were immunized by vaccination or chickenpox disease.
STUDY DESIGN
Non-pregnant females between 18 and 36 years old with a history of VZV immunization (n = 20) or prior chickenpox disease (n = 20) were recruited. IgG antibody titers and T cell responses were measured by flow cytometry-based methods in serum and peripheral blood, respectively.
RESULTS
There were no significant differences in median antibody titers between vaccinated and chickenpox groups (p = 0.34). The chickenpox group had significantly higher levels of VZV antigen-specific CD4 T cells (p = 0.004).
CONCLUSION
Natural infection induced higher VZV-specific T cell immune responses than vaccination.
Identifiants
pubmed: 31959424
pii: S0264-410X(20)30003-7
doi: 10.1016/j.vaccine.2019.12.067
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Chickenpox Vaccine
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1581-1585Subventions
Organisme : NIAID NIH HHS
ID : R24 AI054953
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.