Welding and the risk of head and neck cancer: the ICARE study.
Adolescent
Adult
Aged
Case-Control Studies
France
/ epidemiology
Head and Neck Neoplasms
Humans
Hypopharyngeal Neoplasms
Laryngeal Neoplasms
/ epidemiology
Logistic Models
Male
Middle Aged
Neoplasms, Squamous Cell
/ epidemiology
Occupational Diseases
/ epidemiology
Occupational Exposure
/ adverse effects
Oropharyngeal Neoplasms
Pharyngeal Neoplasms
/ epidemiology
Risk Factors
Welding
Young Adult
Epidemiology
case-contol study
head and neck
occupational health
tumor
Journal
Occupational and environmental medicine
ISSN: 1470-7926
Titre abrégé: Occup Environ Med
Pays: England
ID NLM: 9422759
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
10
07
2019
revised:
14
12
2019
accepted:
21
12
2019
pubmed:
22
1
2020
medline:
25
6
2020
entrez:
22
1
2020
Statut:
ppublish
Résumé
To investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the Analyses were restricted to men (2703 controls and 1588 cases of squamous-cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx). Welding activity and potential confounders were assessed by detailed questionnaires. ORs and CIs (95% CI) were estimated by unconditional logistic regression, adjusted for age, area of residence, tobacco smoking, alcohol consumption and occupational exposure to asbestos. Welding was associated with an increased risk of head and neck cancer overall (OR=1.31, 95% CI 1.03 to 1.67). The association was strongest for laryngeal cancer (OR=1.66, 95% CI 1.15 to 2.38) and the risk increased with the cumulative duration (p-trend <0.01) and the weighted duration (p-trend <0.01) of welding. A cumulative duration and a weighted duration of welding of more than 10 years were also associated with a significantly increased risk of oral cancer (OR=1.82, 95% CI 1.09 to 3.04; OR=2.10, 95% CI 0.99 to 4.45, respectively). A long duration of arc welding was associated with laryngeal cancer, whereas a long duration of spot welding was associated with oral cancer. Welding was not associated with the risk of oropharyngeal and hypopharyngeal cancer. Our findings suggest that welding and several welding-related tasks increase the risk of laryngeal cancer and to a lesser extent oral cancer.
Identifiants
pubmed: 31959638
pii: oemed-2019-106080
doi: 10.1136/oemed-2019-106080
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
293-300Investigateurs
Anne-Valérie Guizard
(AV)
Arlette Danzon
(A)
Anne-Sophie Woronoff
(AS)
Michel Velten
(M)
Antoine Buemi
(A)
Émilie Marrer
(É)
Brigitte Trétarre
(B)
Marc Colonna
(M)
Patricia Delafosse
(P)
Paolo Bercelli
(P)
Florence Molinié
(F)
Simona Bara
(S)
Bénédicte Lapotre-Ledoux
(B)
Nicole Raverdy
(N)
Sylvie Cénée
(S)
Oumar Gaye
(O)
Florence Guida
(F)
Farida Lamkarkach
(F)
Loredana Radoï
(L)
Marie Sanchez
(M)
Isabelle Stücker
(I)
Matthieu Carton
(M)
Diane Cyr
(D)
Annie Schmaus
(A)
Joëlle Févotte
(J)
Corinne Pilorget
(C)
Gwenn Menvielle
(G)
Danièle Luce
(D)
Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.