Sleep Spindles Promote the Restructuring of Memory Representations in Ventromedial Prefrontal Cortex through Enhanced Hippocampal-Cortical Functional Connectivity.
Adolescent
Adult
Brain Mapping
Female
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Memory Consolidation
/ physiology
Memory, Long-Term
/ physiology
Mental Recall
/ physiology
Neural Pathways
/ diagnostic imaging
Polysomnography
Prefrontal Cortex
/ diagnostic imaging
Sleep
/ physiology
Sleep Stages
/ physiology
Young Adult
fMRI
hippocampus
memory consolidation
sleep
sleep spindles
vmPFC
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
26 02 2020
26 02 2020
Historique:
received:
08
08
2019
revised:
06
01
2020
accepted:
08
01
2020
pubmed:
22
1
2020
medline:
18
8
2020
entrez:
22
1
2020
Statut:
ppublish
Résumé
Memory consolidation is hypothesized to involve the distribution and restructuring of memory representations across hippocampal and cortical regions. Theories suggest that, through extended hippocampal-cortical interactions, cortical ensembles come to represent more integrated, or overlapping, memory traces that prioritize commonalities across related memories. Sleep processes, particularly fast sleep spindles, are thought to support consolidation, but evidence for this relationship has been mostly limited to memory retention benefits. Whether fast spindles provide a mechanism for neural changes hypothesized to support consolidation, including the strengthening of hippocampal-cortical networks and integration across memory representations, remains unclear, as does the specificity of regions involved. Using functional connectivity analyses of human fMRI data (both sexes), we show that fast spindle density during overnight sleep is related to enhanced hippocampal-cortical functional connectivity the next day, when restudying information learned before sleep. Spindle density modulated connectivity in distinct hippocampal-cortical networks depending on the category of the consolidated stimuli. Specifically, spindle density correlated with functional connectivity between anterior hippocampus and ventromedial prefrontal cortex (vmPFC) for object-word pairs, and posterior hippocampus and posteromedial cortex for scene-word pairs. Using multivariate pattern analyses, we also show that fast spindle density during postlearning sleep is associated with greater pattern similarity, or representational overlap, across individual object-word memories in vmPFC the next day. Further, the relationship between fast spindle density and representational overlap in vmPFC was mediated by the degree of anterior hippocampal-vmPFC functional connectivity. Together, these results suggest that fast spindles support the network distribution of memory traces, potentially restructuring memory representations in vmPFC.
Identifiants
pubmed: 31959699
pii: JNEUROSCI.1946-19.2020
doi: 10.1523/JNEUROSCI.1946-19.2020
pmc: PMC7046449
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1909-1919Subventions
Organisme : NINDS NIH HHS
ID : K23 NS104252
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH074692
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 the authors.
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