Aneurysmal subarachnoid haemorrhage: Effect of CRHR1 genotype on mental health-related quality of life.
Adult
Aged
Aged, 80 and over
Cohort Studies
Emotions
Female
Genetic Predisposition to Disease
Genotype
Humans
Life Change Events
Male
Mental Disorders
/ etiology
Mental Health
Middle Aged
Polymorphism, Single Nucleotide
Quality of Life
Receptors, Corticotropin-Releasing Hormone
/ genetics
Retrospective Studies
Subarachnoid Hemorrhage
/ genetics
Vitalism
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 01 2020
20 01 2020
Historique:
received:
22
07
2019
accepted:
31
12
2019
entrez:
22
1
2020
pubmed:
22
1
2020
medline:
26
11
2020
Statut:
epublish
Résumé
Quality of life (QoL) disturbances are common after aneurysmal subarachnoid hemorrhage (aSAH) both in physical and mental health domains and their causes are not clearly understood. Corticotropin-releasing hormone receptor 1 (CRHR1) is involved in stress reactivity and development of mental health disturbances after negative life-events. We performed a retrospective cohort study of long-term QoL outcomes among 125 surgically treated aSAH patients (2001-2013). QoL was assessed with Short Form Health Survey (SF-36) and compared to an age and gender matched general population. Genotyping of CRHR1 single nucleotide polymorphisms was performed (Rs7209436, Rs110402, Rs242924) and their effect on QoL scores was explored. aSAH patients experienced a reduced quality of life in all domains. CRHR1 minor genotype was associated with higher SF-36 mental health (OR = 1.31-1.6, p < 0.05), role-emotional (OR = 1.57, p = 0.04) and vitality scores (OR = 1.31-1.38, p < 0.05). Association of all studied SNP's with vitality and Rs242924 with mental health scores remained statistically significant after Bonferroni correction. Mental quality of life scores were associated with physical state of patients, antidepressant history and CRHR1 genotype. Predisposition to mental health disturbances after stressful life-events might be associated with reduced mental QoL after aSAH and selected patients could be provided advanced counselling in the recovery phase.
Identifiants
pubmed: 31959877
doi: 10.1038/s41598-020-57527-4
pii: 10.1038/s41598-020-57527-4
pmc: PMC6971041
doi:
Substances chimiques
Receptors, Corticotropin-Releasing Hormone
0
CRF receptor type 1
5CLY6W2H1M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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