Postradiotherapy persistent lymphopenia as a poor prognostic factor in patients with cervical cancer receiving radiotherapy: a single-center, retrospective study.
Cervical cancer
Lymphopenia
Radiotherapy
Journal
International journal of clinical oncology
ISSN: 1437-7772
Titre abrégé: Int J Clin Oncol
Pays: Japan
ID NLM: 9616295
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
25
09
2019
accepted:
06
01
2020
pubmed:
22
1
2020
medline:
25
7
2020
entrez:
22
1
2020
Statut:
ppublish
Résumé
Radiotherapy (RT) is effective in cervical cancer; radiation-induced lymphopenia correlates with poor survival outcome in several cancer types. We investigated the association of total lymphocyte count (TLC) with survival outcomes in patients with cervical cancer. We retrospectively reviewed 168 patients with cervical cancer initially treated with definitive RT. We obtained clinicopathological data and TLCs before RT and at the end and at 6 months after RT. Patient-, treatment-, and tumor-specific factors were evaluated to determine their predictive values for overall survival. The association of overall and progression-free survivals with lymphopenia at each point was evaluated. Median follow-up duration was 44 (interquartile range: 25-67) months. Median TLCs before RT and at the end and at 6 months after RT were 1625/mm Post-RT persistent lymphopenia could be a poor prognostic factor for patients with cervical cancer who receive RT.
Sections du résumé
BACKGROUND
BACKGROUND
Radiotherapy (RT) is effective in cervical cancer; radiation-induced lymphopenia correlates with poor survival outcome in several cancer types. We investigated the association of total lymphocyte count (TLC) with survival outcomes in patients with cervical cancer.
METHODS
METHODS
We retrospectively reviewed 168 patients with cervical cancer initially treated with definitive RT. We obtained clinicopathological data and TLCs before RT and at the end and at 6 months after RT. Patient-, treatment-, and tumor-specific factors were evaluated to determine their predictive values for overall survival. The association of overall and progression-free survivals with lymphopenia at each point was evaluated.
RESULTS
RESULTS
Median follow-up duration was 44 (interquartile range: 25-67) months. Median TLCs before RT and at the end and at 6 months after RT were 1625/mm
CONCLUSION
CONCLUSIONS
Post-RT persistent lymphopenia could be a poor prognostic factor for patients with cervical cancer who receive RT.
Identifiants
pubmed: 31960184
doi: 10.1007/s10147-020-01623-y
pii: 10.1007/s10147-020-01623-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM