Jumonji domain-containing protein 6 protein and its role in cancer.
JMJD6 protein
cancer
epigenetics
jumonji domain-containing histone demethylases
Journal
Cell proliferation
ISSN: 1365-2184
Titre abrégé: Cell Prolif
Pays: England
ID NLM: 9105195
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
12
10
2019
revised:
29
11
2019
accepted:
02
12
2019
pubmed:
22
1
2020
medline:
7
3
2020
entrez:
22
1
2020
Statut:
ppublish
Résumé
The jumonji domain-containing protein 6 (JMJD6) is a Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of histone and non-histone peptides. Recently, the intrinsic tyrosine kinase activity of JMJD6 has also been reported. The JMJD6 has been implicated in embryonic development, cellular proliferation and migration, self-tolerance induction in the thymus, and adipocyte differentiation. Not surprisingly, abnormal expression of JMJD6 may contribute to the development of many diseases, such as neuropathic pain, foot-and-mouth disease, gestational diabetes mellitus, hepatitis C and various types of cancer. In the present review, we summarized the structure and functions of JMJD6, with particular emphasis on the role of JMJD6 in cancer progression.
Identifiants
pubmed: 31961032
doi: 10.1111/cpr.12747
pmc: PMC7046477
doi:
Substances chimiques
Jumonji Domain-Containing Histone Demethylases
EC 1.14.11.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12747Subventions
Organisme : National Natural Science Foundation of China
ID : 81602492
Organisme : National Key Research and Development Program of China
ID : 2016YFA0201402
Organisme : National Major Scientific, Technological Special Project for "Significant New Drugs Development"
ID : 2018ZX09733001
Organisme : Excellent Youth Foundation of Sichuan Scientific Committee Grant in China
ID : 2019JDJQ0008
Informations de copyright
© 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.
Références
Development. 1996 Feb;122(2):461-72
pubmed: 8625797
Life Sci. 2017 Nov 1;188:163-171
pubmed: 28882645
Genes Dev. 1998 Aug 1;12(15):2424-33
pubmed: 9694806
Front Genet. 2017 Mar 16;8:32
pubmed: 28360925
FASEB J. 2017 Dec;31(12):5356-5370
pubmed: 28790175
J Clin Oncol. 1999 May;17(5):1474-81
pubmed: 10334533
BMC Cell Biol. 2004 Jun 11;5:26
pubmed: 15193161
Cancer Cell. 2006 Jan;9(1):23-32
pubmed: 16413469
Neoplasma. 2017;64(5):700-708
pubmed: 28592121
Mol Cell. 2005 Aug 19;19(4):535-45
pubmed: 16109377
Science. 2009 Jul 3;325(5936):90-3
pubmed: 19574390
Nature. 2017 Jul 20;547(7663):291-292
pubmed: 28678780
Cell. 2012 Jul 6;150(1):12-27
pubmed: 22770212
J Cell Biochem. 2012 May;113(5):1663-70
pubmed: 22189873
Immunology. 2018 Jul;154(3):452-464
pubmed: 29338076
Nat Rev Cancer. 2008 Dec;8(12):976-90
pubmed: 19029958
Cell. 2010 Jun 11;141(6):970-81
pubmed: 20550933
Mol Cell. 2006 Dec 8;24(5):747-757
pubmed: 17157257
J Biol Chem. 1990 May 25;265(15):8573-82
pubmed: 1692833
Oncol Lett. 2013 Nov;6(5):1295-1298
pubmed: 24179511
Science. 2007 Oct 19;318(5849):444-7
pubmed: 17947579
Int J Oncol. 2015 Sep;47(3):900-8
pubmed: 26201960
Nature. 2000 May 4;405(6782):85-90
pubmed: 10811223
Virus Genes. 2017 Jun;53(3):340-351
pubmed: 28364140
Trends Cell Biol. 2010 Nov;20(11):662-71
pubmed: 20863703
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14568-72
pubmed: 20679243
Nat Rev Mol Cell Biol. 2006 May;7(5):359-71
pubmed: 16633338
J Cell Mol Med. 2010 Mar;14(3):528-52
pubmed: 19840194
Pharmacogenomics. 2007 Aug;8(8):909-16
pubmed: 17716226
Virology. 2016 May;492:38-52
pubmed: 26896934
Cell Prolif. 2020 Feb;53(2):e12747
pubmed: 31961032
Trends Genet. 1997 Dec;13(12):485-9
pubmed: 9433138
Endocr Rev. 2011 Oct;32(5):597-622
pubmed: 21680538
J Appl Physiol (1985). 2010 Aug;109(2):598-605
pubmed: 20203073
Br J Cancer. 2005 Mar 14;92(5):921-8
pubmed: 15714203
Oncogene. 2012 Jul 19;31(29):3397-408
pubmed: 22105362
Mol Cell Biol. 2011 Jul;31(13):2641-52
pubmed: 21555454
Chem Soc Rev. 2011 Aug;40(8):4364-97
pubmed: 21390379
Nat Rev Mol Cell Biol. 2004 May;5(5):343-54
pubmed: 15122348
Cancer Res. 2011 Oct 15;71(20):6320-6
pubmed: 21862635
Cell Mol Gastroenterol Hepatol. 2017 Oct 16;5(2):101-112
pubmed: 29693039
Nucleic Acids Res. 2016 Dec 15;44(22):10662-10675
pubmed: 27613418
EMBO Rep. 2011 May;12(5):463-9
pubmed: 21460794
PLoS Biol. 2014 Mar 25;12(3):e1001819
pubmed: 24667498
Nature. 2017 Jul 20;547(7663):355-359
pubmed: 28678782
Nat Rev Mol Cell Biol. 2012 Oct;13(10):616-30
pubmed: 22992590
J Biol Chem. 2001 Jan 12;276(2):1071-7
pubmed: 10986279
J Biol. 2004;3(4):15
pubmed: 15345036
Clin Epigenetics. 2016 Apr 14;8:38
pubmed: 27081402
FEBS Lett. 2012 Jul 4;586(14):1959-70
pubmed: 22710176
Carcinogenesis. 2010 Jan;31(1):27-36
pubmed: 19752007
PLoS One. 2014 Feb 03;9(2):e87982
pubmed: 24498420
Virology. 2014 Mar;452-453:1-11
pubmed: 24606677
Cell Mol Immunol. 2007 Dec;4(6):467-72
pubmed: 18163959
Nature. 2010 Apr 15;464(7291):1071-6
pubmed: 20393566
J Cell Biochem. 2012 May;113(5):1569-80
pubmed: 22174091
Ann Surg Oncol. 2011 May;18(5):1243-50
pubmed: 21327457
Tumour Biol. 2013 Aug;34(4):2397-401
pubmed: 23595221
J Biol Chem. 2013 Mar 1;288(9):6053-62
pubmed: 23303181
Cell Res. 2009 Feb;19(2):156-72
pubmed: 19153598
Development. 2004 Nov;131(21):5417-27
pubmed: 15469976
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):541-6
pubmed: 9892669
PLoS One. 2010 Oct 29;5(10):e13769
pubmed: 21060799
Gene. 2013 Jan 15;513(1):1-13
pubmed: 23123731
J Mol Biol. 2010 Aug 13;401(2):211-22
pubmed: 20684070
J Inorg Biochem. 2006 Apr;100(4):644-69
pubmed: 16513174
BMC Genomics. 2008 Jun 18;9:293
pubmed: 18564434
Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3327-36
pubmed: 26080448
Mol Cell. 2005 Aug 19;19(4):523-34
pubmed: 16109376
Curr Opin Struct Biol. 2010 Dec;20(6):659-72
pubmed: 20888218
Carcinogenesis. 2016 Feb;37(2):119-128
pubmed: 26645717
Nat Struct Biol. 1997 Aug;4(8):657-65
pubmed: 9253416
Nature. 2004 Oct 7;431(7009):712-7
pubmed: 15361884
Mol Cell. 2018 Apr 19;70(2):340-357.e8
pubmed: 29628309
Sci Rep. 2017 Nov 24;7(1):16272
pubmed: 29176719
Int J Cancer. 2019 May 15;144(10):2489-2500
pubmed: 30125344
FEBS J. 2016 Dec;283(24):4462-4473
pubmed: 27813335
Nat Rev Cancer. 2013 Oct;13(10):727-38
pubmed: 24060864
PLoS One. 2015 May 07;10(5):e0126181
pubmed: 25951181
Breast Cancer Res. 2012 May 23;14(3):R85
pubmed: 22621393
J Natl Cancer Inst. 1998 Jun 3;90(11):814-23
pubmed: 9625169
World J Gastroenterol. 2014 Jan 7;20(1):22-30
pubmed: 24415854
J Biol Chem. 2015 Aug 14;290(33):20556-64
pubmed: 26149688
Cell. 2012 Mar 30;149(1):22-35
pubmed: 22464321
Methods Mol Biol. 2015;1238:3-25
pubmed: 25421652
Mol Cancer. 2017 Nov 29;16(1):175
pubmed: 29187213
Curr Opin Struct Biol. 2012 Dec;22(6):691-700
pubmed: 23142576
Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3276-81
pubmed: 21300889
Genes Dev. 2001 Sep 15;15(18):2343-60
pubmed: 11562345
Nature. 2001 Nov 1;414(6859):105-11
pubmed: 11689955
Cancer Treat Rev. 2016 Apr;45:129-38
pubmed: 27017286
Nucleic Acids Res. 2017 Apr 7;45(6):3503-3518
pubmed: 27899633
Biochem Biophys Res Commun. 2012 Jul 20;424(1):58-64
pubmed: 22728043
Nat Rev Clin Oncol. 2016 Jul;13(7):417-30
pubmed: 27030077
Gene Expr. 2015;16(3):101-8
pubmed: 25700366
Cancer Res. 2008 Nov 15;68(22):9107-11
pubmed: 19010878
Biochem J. 2013 Aug 1;453(3):357-70
pubmed: 23688307
Acta Biochim Biophys Sin (Shanghai). 2018 Jan 1;50(1):121-132
pubmed: 29190313
Mol Cell Biochem. 2007 Oct;304(1-2):119-25
pubmed: 17534701
J Endocrinol. 1999 Feb;160(2):257-66
pubmed: 9924195
Expert Opin Ther Targets. 2012 Apr;16 Suppl 2:S17-27
pubmed: 22443084
Biochem J. 2018 Jan 15;475(1):355-371
pubmed: 29229759
Oncogene. 2019 Feb;38(7):980-997
pubmed: 30185813
Chembiochem. 2011 Mar 7;12(4):531-4
pubmed: 22238144
Biochem J. 2015 Jun 1;468(2):191-202
pubmed: 25997831
Front Genet. 2018 Dec 18;9:675
pubmed: 30619488
Gastroenterology. 2010 May;138(5):1920-30
pubmed: 20100483
Mol Cell. 2014 Jun 5;54(5):728-36
pubmed: 24905006
Signal Transduct Target Ther. 2019 Jul 26;4:24
pubmed: 31637004
Cell. 2013 Dec 19;155(7):1581-1595
pubmed: 24360279
Science. 2003 Nov 28;302(5650):1563-6
pubmed: 14645848
Cancer. 2014 Nov 15;120(22):3446-56
pubmed: 24948110
J Cell Biol. 2003 Jul 21;162(2):281-91
pubmed: 12876277
Front Biosci. 2006 Jan 01;11:344-55
pubmed: 16146736
Hepatology. 2018 Mar;67(3):1109-1126
pubmed: 29023917
J Clin Invest. 2003 Mar;111(5):649-58
pubmed: 12618519
Cell. 2012 Mar 30;149(1):214-31
pubmed: 22464331
Cancer Cell. 2014 Jan 13;25(1):21-36
pubmed: 24434208
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8758-63
pubmed: 12840145
Nat Rev Mol Cell Biol. 2007 Apr;8(4):307-18
pubmed: 17342184
Int J Mol Med. 2018 Jul;42(1):633-642
pubmed: 29620141
J Biol Chem. 2015 Sep 4;290(36):22236-49
pubmed: 26221041
J Biol Chem. 2015 Aug 14;290(33):20273-83
pubmed: 26157142
Protein Sci. 2004 May;13(5):1422-5
pubmed: 15075401
Exp Cell Res. 2004 Feb 1;293(1):154-63
pubmed: 14729065
Biochem Biophys Res Commun. 2018 May 15;499(3):711-718
pubmed: 29605300
Trends Biochem Sci. 2001 Jan;26(1):7-9
pubmed: 11165500
Cell Stem Cell. 2007 Oct 11;1(4):389-402
pubmed: 18371377
Mol Cancer. 2018 Nov 22;17(1):164
pubmed: 30466442
Cell Death Differ. 2020 Mar;27(3):1052-1066
pubmed: 31358914
Cancer Cell. 2014 Mar 17;25(3):304-17
pubmed: 24651012
Immunol Lett. 2002 Jun 3;82(1-2):85-91
pubmed: 12008039
Cell. 2017 Jun 1;169(6):985-999
pubmed: 28575679
Biomolecules. 2017 Jun 01;7(2):
pubmed: 28587176