New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells.


Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
16 Jan 2020
Historique:
received: 01 10 2019
revised: 13 01 2020
accepted: 14 01 2020
entrez: 23 1 2020
pubmed: 23 1 2020
medline: 21 10 2020
Statut: epublish

Résumé

Curcumin has been investigated extensively for cancer prevention, but it has been proposed that long-term treatments may promote clonal evolution and gain of cellular resistance, potentially rendering cancer cells less sensitive to future therapeutic interventions. Here, we used long-term, low-dose treatments to determine the potential for adverse effects in non-small cell lung cancer (NSCLC) cells. IC

Identifiants

pubmed: 31963196
pii: molecules25020366
doi: 10.3390/molecules25020366
pmc: PMC7024150
pii:
doi:

Substances chimiques

Antineoplastic Agents, Phytogenic 0
Curcumin IT942ZTH98

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Cancer Research UK
ID : 13101
Pays : United Kingdom
Organisme : Indena SPA
ID : LH01
Organisme : Cancer Research UK
ID : [C10604/A25151].
Pays : United Kingdom

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Auteurs

Gintare Smagurauskaite (G)

Leicester Cancer Research Centre, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK.

Jagdish Mahale (J)

Leicester Cancer Research Centre, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK.

Karen Brown (K)

Leicester Cancer Research Centre, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK.

Anne L Thomas (AL)

Leicester Cancer Research Centre, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK.

Lynne M Howells (LM)

Leicester Cancer Research Centre, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK.

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Classifications MeSH