Microtubules in Polyomavirus Infection.
T antigens
VP1 capsid protein
cell cycle block
dynein
kinesin
microtubules
molecular motors
polyomavirus
virus
virus trafficking
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
18 01 2020
18 01 2020
Historique:
received:
10
01
2020
revised:
15
01
2020
accepted:
16
01
2020
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
18
2
2021
Statut:
epublish
Résumé
Microtubules, part of the cytoskeleton, are indispensable for intracellular movement, cell division, and maintaining cell shape and polarity. In addition, microtubules play an important role in viral infection. In this review, we summarize the role of the microtubules' network during polyomavirus infection. Polyomaviruses usurp microtubules and their motors to travel via early and late acidic endosomes to the endoplasmic reticulum. As shown for SV40, kinesin-1 and microtubules are engaged in the release of partially disassembled virus from the endoplasmic reticulum to the cytosol, and dynein apparently assists in the further disassembly of virions prior to their translocation to the cell nucleus-the place of their replication. Polyomavirus gene products affect the regulation of microtubule dynamics. Early T antigens destabilize microtubules and cause aberrant mitosis. The role of these activities in tumorigenesis has been documented
Identifiants
pubmed: 31963741
pii: v12010121
doi: 10.3390/v12010121
pmc: PMC7019765
pii:
doi:
Substances chimiques
Capsid Proteins
0
VP1 protein, polyomavirus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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