Epidemiology of knee osteoarthritis in general practice: a registry-based study.
knee
musculoskeletal disorders
primary care
public health
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
20 01 2020
20 01 2020
Historique:
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
11
2
2021
Statut:
epublish
Résumé
The present study investigated (1) trends in the prevalence and incidence of knee osteoarthritis over a 20-year period (1996-2015); (2) trends in multimorbidity and (3) trends in drug prescriptions. Registry-based study. Primary healthcare, Flanders, Belgium. Data were collected from Intego, a general practice-based morbidity registration network. In the study period between 1996 and 2015, data from 440 140 unique patients were available. Trends in prevalence and incidence rate of knee osteoarthritis were computed using joinpoint regression analysis. The mean disease count was calculated to assess trends in multimorbidity. In addition, the number of drug prescriptions was identified by the Anatomical Therapeutic Chemical Classification code and trends were equally recorded with joinpoint regression. The total age-standardised prevalence of knee osteoarthritis increased from 2.0% in 1996 to 3.6% in 2015. An upward trend was observed with an average annual percentage change (AAPC) of 2.5 (95% CI 2.2 to 2.9). In 2015, the prevalence rates in the 10 year age groups from the 45-54 years age group onwards were 3.1%, 5.6%, 9.0% and 13.9%, to reach 15.0% in people aged 85 years and older. The incidence remained stable with 3.75‰ in 2015 (AAPC=-0.5, 95% CI -1.4 to 0.5). The mean disease count significantly increased from 1.63 to 2.34 (p<0.001) for incident cases with knee osteoarthritis. Finally, we observed a significantly positive trend in the overall prescription of acetaminophen (AAPC=6.7, 95% CI 5.6 to 7.7), weak opioids (AAPC=4.0, 95% CI 0.9 to 7.3) and glucosamine (AAPC=8.6, 95% CI 2.4 to 15.1). Oral non-steroidal anti-inflammatory drugs were most prescribed, with a prevalence rate of 29.8% in 2015, but remained stable during the study period (AAPC=0.0, 95% CI -1.1 to 1.1). Increased prevalence, multimorbidity, and number of drug prescriptions confirm an increased burden of knee osteoarthritis. In future, these trends can be used to prioritise initiatives for improvement in care.
Identifiants
pubmed: 31964664
pii: bmjopen-2019-031734
doi: 10.1136/bmjopen-2019-031734
pmc: PMC7044813
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e031734Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
NCHS Data Brief. 2012 Jul;(100):1-8
pubmed: 23101759
Rheumatology (Oxford). 2014 May;53(5):937-47
pubmed: 24489012
Semin Arthritis Rheum. 2018 Jun;47(6):805-813
pubmed: 29157670
Ann Rheum Dis. 2013 Jul;72(7):1125-35
pubmed: 23595142
Fam Pract. 2005 Feb;22(1):103-8
pubmed: 15640302
PLoS One. 2019 Feb 12;14(2):e0212046
pubmed: 30753214
Fam Pract. 2005 Aug;22(4):442-7
pubmed: 15964863
Evid Based Med. 2016 Feb;21(1):14
pubmed: 26483324
BMC Musculoskelet Disord. 2008 Jun 26;9:95
pubmed: 18582362
Fam Pract. 1992 Mar;9(1):15-21
pubmed: 1634021
Stat Med. 2009 Dec 20;28(29):3670-82
pubmed: 19856324
Ann Rheum Dis. 2014 Jul;73(7):1323-30
pubmed: 24553908
Arch Otolaryngol Head Neck Surg. 2002 Oct;128(10):1172-9
pubmed: 12365889
Telemed J E Health. 2017 Mar;23(3):248-253
pubmed: 27333468
Osteoarthritis Cartilage. 2014 Mar;22(3):363-88
pubmed: 24462672
Eur J Gen Pract. 2008;14 Suppl 1:28-32
pubmed: 18949641
J Arthroplasty. 2004 Sep;19(6):700-5
pubmed: 15343528
BMC Cardiovasc Disord. 2016 Mar 28;16:61
pubmed: 27021333
Lancet. 2012 Dec 15;380(9859):2163-96
pubmed: 23245607
BMJ. 2015 Mar 31;350:h1225
pubmed: 25828856
J Am Geriatr Soc. 1968 May;16(5):622-6
pubmed: 5646906
Br Med Bull. 2013;105:185-99
pubmed: 23337796
Stat Med. 2000 Feb 15;19(3):335-51
pubmed: 10649300
Fam Pract. 2006 Apr;23(2):151-8
pubmed: 16464870
BMC Fam Pract. 2014 Apr 07;15:61
pubmed: 24708798
PLoS Med. 2015 Oct 06;12(10):e1001885
pubmed: 26440803
Fam Pract. 2002 Oct;19(5):543-6
pubmed: 12356710
J Chronic Dis. 1987;40(5):373-83
pubmed: 3558716
Arthritis Care Res (Hoboken). 2012 Apr;64(4):465-74
pubmed: 22563589
Ochsner J. 2002 Fall;4(4):211-4
pubmed: 22826660
Br J Gen Pract. 2015 Aug;65(637):e530-7
pubmed: 26212849
Arthritis Care Res (Hoboken). 2017 Jun;69(6):807-816
pubmed: 27563831
Lancet. 2012 Dec 15;380(9859):2197-223
pubmed: 23245608
Physiother Theory Pract. 2015 Feb;31(2):107-13
pubmed: 25495877
Clin Rheumatol. 2010 Jul;29(7):739-47
pubmed: 20177725
Ann Rheum Dis. 2004 Apr;63(4):408-14
pubmed: 15020335
Fam Pract. 2013 Jun;30(3):347-54
pubmed: 23307818
BMC Med Inform Decis Mak. 2014 Jun 06;14:48
pubmed: 24906941