Gαi2
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 01 2020
21 01 2020
Historique:
received:
16
10
2019
accepted:
24
12
2019
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
18
12
2020
Statut:
epublish
Résumé
Pheromone detection by the vomeronasal organ (VNO) mediates important social behaviors across different species, including aggression and sexual behavior. However, the relationship between vomeronasal function and social hierarchy has not been analyzed reliably. We evaluated the role of pheromone detection by receptors expressed in the apical layer of the VNO such as vomeronasal type 1 receptors (V1R) in dominance behavior by using a conditional knockout mouse for G protein subunit Gαi2, which is essential for V1R signaling. We used the tube test as a model to analyze the within-a-cage hierarchy in male mice, but also as a paradigm of novel territorial competition in animals from different cages. In absence of prior social experience, Gαi2 deletion promotes winning a novel social competition with an unfamiliar control mouse but had no effect on an established hierarchy in cages with mixed genotypes, both Gαi2
Identifiants
pubmed: 31965032
doi: 10.1038/s41598-020-57765-6
pii: 10.1038/s41598-020-57765-6
pmc: PMC6972791
doi:
Substances chimiques
Pheromones
0
GTP-Binding Protein alpha Subunit, Gi2
EC 3.6.5.1
Gnai2 protein, mouse
EC 3.6.5.1
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
894Subventions
Organisme : Intramural NIH HHS
ID : Z01 ES101643
Pays : United States
Références
Wolff, J. O. & Sherman, P. W. Rodent societies: an ecological and evolutionary perspective. (University of Chicago Press, 2008).
Laskowski, K. L., Wolf, M. & Bierbach, D. The making of winners (and losers): how early dominance interactions determine adult social structure in a clonal fish. Proc Biol Sci 283, https://doi.org/10.1098/rspb.2016.0183 (2016).
doi: 10.1098/rspb.2016.0183
Latham, N. & Mason, G. From house mouse to mouse house: the behavioural biology of free-living Mus musculus and its implications in the laboratory. Applied Animal Behav. Science 86, 261–289 (2004).
doi: 10.1016/j.applanim.2004.02.006
Holy, T. E., Dulac, C. & Meister, M. Responses of vomeronasal neurons to natural stimuli. Science 289, 1569–1572, https://doi.org/10.1126/science.289.5484.1569 (2000).
doi: 10.1126/science.289.5484.1569
pubmed: 10968796
Mohrhardt, J., Nagel, M., Fleck, D., Ben-Shaul, Y. & Spehr, M. Signal Detection and Coding in the Accessory Olfactory System. Chem Senses 43, 667–695, https://doi.org/10.1093/chemse/bjy061 (2018).
doi: 10.1093/chemse/bjy061
pubmed: 30256909
pmcid: 6211456
Stowers, L. & Kuo, T. H. Mammalian pheromones: emerging properties and mechanisms of detection. Curr Opin Neurobiol 34, 103–109, https://doi.org/10.1016/j.conb.2015.02.005 (2015).
doi: 10.1016/j.conb.2015.02.005
pubmed: 25747731
pmcid: 4561034
Chamero, P. et al. Identification of protein pheromones that promote aggressive behaviour. Nature 450, 899–902, https://doi.org/10.1038/nature05997 (2007).
doi: 10.1038/nature05997
pubmed: 18064011
Hausfater, G., Altmann, J. & Altmann, S. Long-Term Consistency of Dominance Relations Among Female Baboons (Papio cynocephalus). Science 217, 752–755, https://doi.org/10.1126/science.217.4561.752 (1982).
doi: 10.1126/science.217.4561.752
pubmed: 17772319
Rose, R. M., Holaday, J. W. & Bernstein, I. S. Plasma testosterone, dominance rank and aggressive behaviour in male rhesus monkeys. Nature 231, 366–368, https://doi.org/10.1038/231366a0 (1971).
doi: 10.1038/231366a0
pubmed: 4996062
Stagkourakis, S. et al. A neural network for intermale aggression to establish social hierarchy. Nat Neurosci 21, 834–842, https://doi.org/10.1038/s41593-018-0153-x (2018).
doi: 10.1038/s41593-018-0153-x
pubmed: 29802391
Syme, G. J. Competitive orders as measures of social dominance. Animal Behaviour 22, 931–940 (1974).
doi: 10.1016/0003-3472(74)90016-5
Francis, R. C. The effects of bidirectional selection for social dominance on agonistic behavior and sex ratios in the paradise fish (Macropodus opercularis). Behaviour 90, 25–45 (1984).
doi: 10.1163/156853984X00542
Benton, D., Dalrymple-Alford, J. C. & Brain, P. F. Comparisons of measures of dominance in the laboratory mouse. Animal Behaviour 28, 1274–1279 (1980).
doi: 10.1016/S0003-3472(80)80115-1
Wang, F., Kessels, H. W. & Hu, H. The mouse that roared: neural mechanisms of social hierarchy. Trends Neurosci 37, 674–682, https://doi.org/10.1016/j.tins.2014.07.005 (2014).
doi: 10.1016/j.tins.2014.07.005
pubmed: 25160682
Lindzey, G., Winston, H. & Manosevitz, M. Social dominance in inbred mouse strains. Nature 191, 474–476, https://doi.org/10.1038/191474a0 (1961).
doi: 10.1038/191474a0
pubmed: 13762409
Wang, F. et al. Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science 334, 693–697, https://doi.org/10.1126/science.1209951 (2011).
doi: 10.1126/science.1209951
pubmed: 21960531
Chamero, P. et al. G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. Proc Natl Acad Sci USA 108, 12898–12903, https://doi.org/10.1073/pnas.1107770108 (2011).
doi: 10.1073/pnas.1107770108
pubmed: 21768373
Zufall, F. TRPs in olfaction. Handb Exp Pharmacol 223, 917–933, https://doi.org/10.1007/978-3-319-05161-1_8 (2014).
doi: 10.1007/978-3-319-05161-1_8
pubmed: 24961974
Trouillet, A. C. et al. Central role of G protein Galphai2 and Galphai2(+) vomeronasal neurons in balancing territorial and infant-directed aggression of male mice. Proc Natl Acad Sci USA 116, 5135–5143, https://doi.org/10.1073/pnas.1821492116 (2019).
doi: 10.1073/pnas.1821492116
pubmed: 30804203
Palle, A. et al. Social dominance differentially alters gene expression in the medial prefrontal cortex without affecting adult hippocampal neurogenesis or stress and anxiety-like behavior. FASEB J 33, 6995–7008, https://doi.org/10.1096/fj.201801600R (2019).
doi: 10.1096/fj.201801600R
pubmed: 30857420
So, N., Franks, B., Lim, S. & Curley, J. P. A Social Network Approach Reveals Associations between Mouse Social Dominance and Brain Gene Expression. PLoS One 10, e0134509, https://doi.org/10.1371/journal.pone.0134509 (2015).
doi: 10.1371/journal.pone.0134509
pubmed: 26226265
pmcid: 4520683
Bluthe, R. M. & Dantzer, R. Role of the vomeronasal system in vasopressinergic modulation of social recognition in rats. Brain Res 604, 205–210, https://doi.org/10.1016/0006-8993(93)90370-3 (1993).
doi: 10.1016/0006-8993(93)90370-3
pubmed: 8457849
Krames, L., Carr, W. J. & Bergman, B. A pheromone associated with social dominance among male rats. Psychonomic Science 16, 11–12 (1969).
doi: 10.3758/BF03331885
Leypold, B. G. et al. Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci USA 99, 6376–6381, https://doi.org/10.1073/pnas.082127599 (2002).
doi: 10.1073/pnas.082127599
pubmed: 11972034
Stowers, L., Holy, T. E., Meister, M., Dulac, C. & Koentges, G. Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295, 1493–1500, https://doi.org/10.1126/science.1069259 (2002).
doi: 10.1126/science.1069259
pubmed: 11823606
Isogai, Y. et al. Multisensory Logic of Infant-Directed Aggression by Males. Cell 175, 1827–1841 e1817, https://doi.org/10.1016/j.cell.2018.11.032 (2018).
doi: 10.1016/j.cell.2018.11.032
pubmed: 30550786
pmcid: 6558521
Mohedano-Moriano, A. et al. Segregated pathways to the vomeronasal amygdala: differential projections from the anterior and posterior divisions of the accessory olfactory bulb. Eur J Neurosci 25(7), 2065–80, https://doi.org/10.1111/j.1460-9568.2007.05472.x (2007).
doi: 10.1111/j.1460-9568.2007.05472.x
pubmed: 17419754
Pardo-Bellver, C. et al. Differential efferent projections of the anterior, posteroventral, and posterodorsal subdivisions of the medial amygdala in mice. Front Neuroanat 6, 33, https://doi.org/10.3389/fnana.2012.00033 (2012).
doi: 10.3389/fnana.2012.00033
pubmed: 22933993
pmcid: 3423790
Felix-Ortiz, A.C. et al. Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex. Neuroscience 321, 197–209, https://doi.org/10.1016/j.neuroscience.2015.07.041 (2016).
doi: 10.1016/j.neuroscience.2015.07.041
pubmed: 26204817
Lindzey, G., Winston, H., and Manosevitz, M., Social Dominance in Inbred Mouse Strains. Nature 191, 474–476 (1961).
doi: 10.1016/j.cell.2018.11.032
pubmed: 30550786
pmcid: 6558521