Eosinophilic cytoplasmic inclusions in type 2 papillary renal cell carcinoma.
Aggressive behavior
Eosinophilic cytoplasmatic inclusions
Pppillary renal cell carcinoma
Sarcomatoid differentiation
Journal
Pathologica
ISSN: 1591-951X
Titre abrégé: Pathologica
Pays: Italy
ID NLM: 0401123
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
26
09
2019
accepted:
11
11
2019
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
27
6
2020
Statut:
ppublish
Résumé
A case of a patient with type 2 papillary renal cell carcinoma with eosinophilic cytoplasmatic inclusions is presented. About 50% of tumor cells were characterized by a well-circumscribed intra-cytoplasmatic round-to-oval or irregular inclusion/globule. Inclusions were 7-30 micron in diameter. They were glassy and pale to slightly eosinophilic in color in hematoxylin and eosin, were stained red by trichrome and were negative for periodic acid-Schiff reaction. Immunohistochemically, globules were negative for PAX8, epithelial membrane antigen, Carbonic Anhydrase IX, pan-cytokeratin (AE1/AE3), CD10, S100 protein, α-smooth-muscle actin, cytokeratin 7 and cytokeratin 34βE12. Glassy hyaline globules were not detected in any adjacent normal kidney cells. The presence of eosinophilic cytoplasmic inclusions in renal cell carcinoma, especially in papillary renal cell carcinoma, has been rarely emphasized in the literature. In this article, we review similar cases in the literature and discuss the nature of eosinophilic globules.
Identifiants
pubmed: 31965115
doi: 10.32074/1591-951X-28-19
pmc: PMC8145672
doi:
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
369-374Informations de copyright
Copyright © 2019 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.
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