Key considerations in reviewing "a comparison of the outcomes between surgical resection and proton beam therapy for single primary hepatocellular carcinoma": the importance of scientific objective perspectives in clinical studies.

Proton beam therapy and carbon-ion radiotherapy, also known as particle beam therapy, are gaining popularity in cancer care and liver tumor treatment is one of the main areas of interest. Comparative studies are in high demand and the article highlights this. While the data presented in this article are without doubt valuable, we raise concerns about their interpretation.