Effect of Gender and Age on Voriconazole Trough Concentrations in Italian Adult Patients.
Adult
Age Factors
Aged
Antifungal Agents
/ administration & dosage
Body Mass Index
Chromatography, High Pressure Liquid
Cohort Studies
Creatinine
/ blood
Dose-Response Relationship, Drug
Female
Humans
Invasive Fungal Infections
/ drug therapy
Italy
Male
Middle Aged
Retrospective Studies
Sex Factors
Voriconazole
/ administration & dosage
Journal
European journal of drug metabolism and pharmacokinetics
ISSN: 2107-0180
Titre abrégé: Eur J Drug Metab Pharmacokinet
Pays: France
ID NLM: 7608491
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
pubmed:
23
1
2020
medline:
10
4
2021
entrez:
23
1
2020
Statut:
ppublish
Résumé
The broad-spectrum triazole antifungal agent, voriconazole, is widely used in the treatment of invasive fungal infections. Its treatment efficacy and the occurrence of adverse events are associated with plasma drug concentration, rendering inconsistent or inadequate dosing in many patients. The aim of this study was to evaluate the effect of gender, age, body mass index, ethnicity, serum creatinine and drug dose on voriconazole trough concentration. A fully validated chromatographic method was used to quantify voriconazole concentration in plasma collected from adult patients at the end of dosing interval. Associations between variables were tested using the Pearson test. The Mann-Whitney U test was used to probe the influence of categorical variables on continuous ones. In a cohort of 330 Italian patients treated with voriconazole, males reported a significantly higher drug concentration than females, with values higher than 1000 ng/mL. Moreover, in the univariate analysis, a significant correlation was found between trough concentration and increasing age. Increasing age and gender could influence voriconazole trough concentrations.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
The broad-spectrum triazole antifungal agent, voriconazole, is widely used in the treatment of invasive fungal infections. Its treatment efficacy and the occurrence of adverse events are associated with plasma drug concentration, rendering inconsistent or inadequate dosing in many patients. The aim of this study was to evaluate the effect of gender, age, body mass index, ethnicity, serum creatinine and drug dose on voriconazole trough concentration.
METHODS
METHODS
A fully validated chromatographic method was used to quantify voriconazole concentration in plasma collected from adult patients at the end of dosing interval. Associations between variables were tested using the Pearson test. The Mann-Whitney U test was used to probe the influence of categorical variables on continuous ones.
RESULTS
RESULTS
In a cohort of 330 Italian patients treated with voriconazole, males reported a significantly higher drug concentration than females, with values higher than 1000 ng/mL. Moreover, in the univariate analysis, a significant correlation was found between trough concentration and increasing age.
CONCLUSION
CONCLUSIONS
Increasing age and gender could influence voriconazole trough concentrations.
Identifiants
pubmed: 31965553
doi: 10.1007/s13318-019-00603-6
pii: 10.1007/s13318-019-00603-6
doi:
Substances chimiques
Antifungal Agents
0
Creatinine
AYI8EX34EU
Voriconazole
JFU09I87TR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM