Chaperone-mediated autophagy in cancer: Advances from bench to bedside.
Journal
Histology and histopathology
ISSN: 1699-5848
Titre abrégé: Histol Histopathol
Pays: Spain
ID NLM: 8609357
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
pubmed:
23
1
2020
medline:
14
4
2021
entrez:
23
1
2020
Statut:
ppublish
Résumé
Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in the pathway being strongly associated with disease. Recently, accumulating evidence has demonstrated a consistent increase in basal CMA activity in a wide array of cancer cell lines and human tumor biopsies, suggesting a potential link between CMA and cancer. On the other hand, an anti-oncogenic role for CMA under physiological conditions in non-transformed cells is also proposed despite the pro-tumorigenic function of CMA in cancer cells. The growing number of connections between CMA and cancers has generated interest in modulating CMA activity for therapeutic purposes. Here, we describe recent advances in the understanding of the molecular regulation of CMA, and discuss the evidence in support of the contribution of CMA dysfunction to cancers.
Identifiants
pubmed: 31965560
pii: HH-18-202
doi: 10.14670/HH-18-202
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
637-644Subventions
Organisme : National Natural Science Foundation of China
ID : 81773206
Organisme : National Natural Science Foundation of China
ID : 81925028
Organisme : National Natural Science Foundation of China
ID : 81672538
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