Interactions between amyloid precursor protein-like (APPL) and MAGUK scaffolding proteins contribute to appetitive long-term memory in
Animals
Animals, Genetically Modified
Appetitive Behavior
/ physiology
Calcium-Calmodulin-Dependent Protein Kinases
/ metabolism
Drosophila Proteins
/ metabolism
Drosophila melanogaster
/ physiology
Membrane Proteins
/ metabolism
Memory, Long-Term
/ physiology
Mushroom Bodies
/ physiology
Nerve Tissue Proteins
/ metabolism
Tumor Suppressor Proteins
/ metabolism
Amyloid precursor protein
CASK
Dlg
Drosophila
MAGUK proteins
long-term memory
mushroom bodies
Journal
Journal of neurogenetics
ISSN: 1563-5260
Titre abrégé: J Neurogenet
Pays: England
ID NLM: 8406473
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
pubmed:
23
1
2020
medline:
29
6
2021
entrez:
23
1
2020
Statut:
ppublish
Résumé
Amyloid precursor protein (APP), the precursor of amyloid beta peptide, plays a central role in Alzheimer's disease (AD), a pathology characterized by memory decline and synaptic loss upon aging. Understanding the physiological role of APP is fundamental in deciphering the progression of AD, and several studies suggest a synaptic function via protein-protein interactions. Nevertheless, it remains unclear whether and how these interactions contribute to memory. In
Identifiants
pubmed: 31965876
doi: 10.1080/01677063.2020.1712597
doi:
Substances chimiques
Appl protein, Drosophila
0
Drosophila Proteins
0
Membrane Proteins
0
Nerve Tissue Proteins
0
Tumor Suppressor Proteins
0
dlg1 protein, Drosophila
143513-41-1
CASK protein, Drosophila
EC 2.7.11.17
Calcium-Calmodulin-Dependent Protein Kinases
EC 2.7.11.17
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM