MULTILOCULAR PURE LEYDIG CELL TUMOR OF OVARY, FALLOPIAN TUBE, AND EXTRAOVARIAN SOFT TISSUE.
Journal
AACE clinical case reports
ISSN: 2376-0605
Titre abrégé: AACE Clin Case Rep
Pays: United States
ID NLM: 101670593
Informations de publication
Date de publication:
Historique:
received:
19
07
2018
accepted:
24
07
2018
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
23
1
2020
Statut:
epublish
Résumé
Leydig cell tumors (LCTs) of the ovary may produce androgens and cause virilization. Although they are generally benign, these tumors are typically very small, making them hard to detect by imaging processes. We report a case of a multilocular LCT involving the ovarian stroma, fallopian tube, and extra-ovarian soft tissue. It was diagnosed by catheter blood sampling of ovarian and adrenal venous blood. A 63-year-old female presented to the endocrinology department with progressive hirsutism and male pattern alopecia occurring within 1 year. Laboratory tests revealed high serum testosterone. Diagnosis of an androgen-producing tumor was considered, however computed tomography and magnetic resonance imaging scans did not show any conspicuous results. Gynecological examination showed slightly enlarged ovaries. Ovarian and adrenal venous blood sampling was performed via catheter for further diagnostics. The testosterone concentration from the right ovarian vein was highly elevated. The patient was admitted for surgery to the gynecological department and bilateral adnexectomy was performed. Microscopic examination showed a multilocular LCT of the right ovary which was located in the ovarian stroma, the fallopian tube, and the extraovarian soft tissue. Following the surgery, her hirsutism disappeared and serum testosterone decreased to normal levels. LCTs typically present with postmenopausal virilization. Catheter blood sampling is a reliable method for diagnosis. Furthermore, follow up is essential as ovarian LCTs often have multilocular presentation.
Identifiants
pubmed: 31966993
doi: 10.4158/ACCR-2018-0240
pmc: PMC6876968
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e16-e21Informations de copyright
Copyright © 2019 AACE.
Déclaration de conflit d'intérêts
DISCLOSURE The authors have no multiplicity of interest to disclose.
Références
Hum Reprod. 2002 Jun;17(6):1468-71
pubmed: 12042263
Cancer. 1973 Oct;32(4):940-51
pubmed: 4751924
Int J Gynecol Pathol. 2010 Jul;29(4):315-20
pubmed: 20567142
Int J Gynecol Pathol. 1989;8(4):299-310
pubmed: 2553628
J Clin Pathol. 1972 Feb;25(2):106-10
pubmed: 4111709
Eur J Endocrinol. 2016 Aug;175(2):G1-G34
pubmed: 27390021
Ann Dermatol Venereol. 2001 Nov;128(11):1241-4
pubmed: 11908171
J Obstet Gynaecol Br Commonw. 1961 Jun;68:451-8
pubmed: 13776111
Exp Clin Endocrinol Diabetes. 2010 May;118(5):291-7
pubmed: 20198556
Eur J Endocrinol. 2015 Feb;172(2):R79-91
pubmed: 25225480
Clin Endocrinol (Oxf). 1994 Nov;41(5):571-6
pubmed: 7828344
J Clin Endocrinol Metab. 2012 Aug;97(8):2584-8
pubmed: 22669303
Cancer. 1973 Oct;32(4):952-60
pubmed: 4751925
Med Klin (Munich). 2007 Mar 15;102(3):259-62
pubmed: 17345023