The Q
Leishmania donovani
Trypanosoma cruzi
cytochrome b
drug target
mechanism of action
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
13 03 2020
13 03 2020
Historique:
pubmed:
23
1
2020
medline:
28
1
2021
entrez:
23
1
2020
Statut:
ppublish
Résumé
Available treatments for Chagas' disease and visceral leishmaniasis are inadequate, and there is a pressing need for new therapeutics. Drug discovery efforts for both diseases principally rely upon phenotypic screening. However, the optimization of phenotypically active compounds is hindered by a lack of information regarding their molecular target(s). To combat this issue we initiate target deconvolution studies at an early stage. Here, we describe comprehensive genetic and biochemical studies to determine the targets of three unrelated phenotypically active compounds. All three structurally diverse compounds target the Q
Identifiants
pubmed: 31967783
doi: 10.1021/acsinfecdis.9b00426
pmc: PMC7076694
doi:
Substances chimiques
Antiparasitic Agents
0
Cytochromes b
9035-37-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
515-528Subventions
Organisme : Wellcome Trust
ID : 203134
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204672/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 092340
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 105021
Pays : United Kingdom
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